WAY-100635, tritiated on the methoxy group. WAY-100635 acts as an antagonist at serotonin 5-HT1A receptors. It also acts as an agonist at dopamine D4 receptors. WAY-100635 is on a scheduled release and is available on the second Monday in February and August.
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WAY-100635 acts as an antagonist at 5-HT1A receptors, and as an agonist at dopamine D4 receptors. The serotonin 5-HT1A receptors belong to a group of GPCRs that are involved in neuromodulation, and are potential drug targets for anxiety and depression. Dopamine D4 receptors are part of a group of GPCRs that are potential drug targets for schizophrenia, bipolar disorder, ADHD, and Parkinson disease.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
|Fresh Lot Days||Second Monday in February and August|
|Label Position||Specifically Labeled|
|Product Brand Name||NEN Radiochemicals|
|Shipping Condition||Dry Ice|
|Special Ordering Information||This is a radioactive product - shipping address must have a license to receive radioactive materials.|
|Therapeutic Area||CNS & Neurologic|
|Unit Size||250 µCi|