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TCP, [Piperdyl-3,4-3H(N)]-

Tenocyclidine (TCP), tritiated at the piperdyl-3,4 position. TCP acts as an antagonist at N-methyl-D-aspartate receptor (NMDA receptors).

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NET886025UC
25 µCi
911.00 EUR
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NET886250UC
250 µCi
3321.00 EUR
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Detail Information

TCP acts as an antagonist at N-methyl-D-aspartate receptor (NMDA receptors), and is a dissociative anesthetic drug with hallucinogenic effects.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET886:

  1. Z. Kawakami, H. Kanno, T. Ueki, K. Terawaki, M. Tabuchi, Y. Ikarashi, Y. Kase, Neuroprotective effects of yokukansan, a traditional japanese medicine, on glutamate-mediated excitotoxicity in cultured cells, Neuroscience, Volume 159, Issue 4, 2009, Pages 1397-1407.
  2. Matthew A. Sills, Graham Fagg, Mario Pozza, Christof Angst, Derek E. Brundish, Stephen D. Hurt, E. Jay Wilusz, Michael Williams, [3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain, European Journal of Pharmacology, Volume 192, Issue 1, 1991, Pages 19-24.

Specifications

Detection Method Radiometric
Label Position Nominally Labeled
Molecular Weight 249.24
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Unit Size 25 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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