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Spiperone (Spiroperidol), [Benzene ring-3H]-, 1mCi (37MBq)

Spiperone, tritiated on the benzene ring. Spiperone acts as an antagonist at Dopamine D2 and D3 receptors, 5-HT1A, 5-HT2A, and alpha-adrenergic receptors (α adrenoreceptors).

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Part Number Unit Size List Price Your Price Quantity
NET565001MC 1 mCi 4974.00 EUR
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Spiperone acts as an antagonist at Dopamine D2 and D3 receptors, 5-HT1A, 5-HT2A, and alpha-adrenergic receptors (α adrenoreceptors), and is used to treat schizophernia.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET565:

  1. Jeong J, Park Y-U, Kim D-K, Lee S, Kwak Y, Lee S-A, et al. (2013) Cdk5 Phosphorylates Dopamine D2 Receptor and Attenuates Downstream Signaling. PLoS ONE 8(12): e84482.
  2. Gerlach, M., Double, K., Arzberger, T. et al. (2003) Dopamine receptor agonists in current clinical use: comparative dopamine receptor binding profiles defined in the human striatum. J Neural Transm, 110: 1119-1127.


Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 395.5
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 1 mCi