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SPIPERONE, [3H]

Tritiated Spiperone. Spiperone acts as an antagonist at Dopamine D2 and D3 receptors, 5-HT1A, 5-HT2A, and alpha-adrenergic receptors (α adrenoreceptors).

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NET1187250UC
2659.00 EUR
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Detail Information

Spiperone is a dopamine D2 antagonist, and is used to treat schizophernia.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1187:

  1. Rorabaugh JM, Stratford JM, Zahniser NR (2014) A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 395.47
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Dopamine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Inflammation
Unit Size 250 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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