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SCH 23390, [N-Methyl-3H]-, 25µCi (925kBq)

SCH-23390 (halobenzazepine), tritiated on the N-methyl group. SCH-23390 acts as an antagonist at the dopamine D1 receptor.

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Part Number Unit Size List Price Your Price Quantity
NET930025UC 25 µCi 732.00 EUR
NET930250UC 250 µCi 2435.00 EUR
NET930001MC 1 mCi 4003.00 EUR
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Overview

SCH-23390 acts as an antagonist at the dopamine D1 receptor. These receptors belong a family of GPCRs and are potential drug targets for Parkinson's disease, schizophrenia, and depression.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET930:

  1. Finnema, S.J., Bang-Andersen, B., Jørgensen, M., Christoffersen, C.T., Gulyás, B., Wikström, H.V., Farde, L. and Halldin, C. (2013), The dopamine D1 receptor agonist (S)-[11C]N-methyl-NNC 01-0259 is not sensitive to changes in dopamine concentration—a positron emission tomography examination in the monkey brain. Synapse, 67: 586–595.
  2. Wong, J., Clifford, J., Massalas, J., Finkelstein, D., Horne, M., Waddington, J., Drago, J. (2003) Neurochemical changes in dopamine D1, D3 and D1/D3 receptor knockout mice, European Journal of Pharmacology, 472 (1–2): 39-47.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 287.8
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Dopamine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 25 µCi