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Sauvagine, [125I]-Tyr0], 10µCi

Sauvagine, labeled with 125I on the tyrosine 0 residue. Sauvagine is a neuropeptide that acts as an agonist at corticotropin-releasing factor receptors (CRF receptors) 1 and 2.

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NEX306010UC
10 µCi
1282.00 EUR
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NEX306050UC
50 µCi
2665.00 EUR
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX306:

  1. Oakley, R.H., Olivares-Reyes, J.A., Hudson, C.C., Flores-Vega, F., Dautzenberg, F.M., Hauger, R.L. (2007), Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses. Am J Phsiol Regul Integr Comp Physiol., 293 (1): R209-222.
  2. Million, M., Grigoriadis, D.E., Sullivan, S., Crowe, P.D., McRoberts, J.A., Zhou, H., Saunders, P.R., Maillot, C., Mayer, E.A., Taché, Y. (2003), A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res, 985 (1): 32-42.

Specifications

Detection Method Radiometric
Fresh Lot Days Fourth Monday of each month
Label Position Nominally Labeled
Molecular Weight 4778.0
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Corticotropin-Releasing Factor
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Inflammation
Unit Size 10 µCi