PerkinElmer
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RO 15-4513, [7,9-3H]-, 250µCi (9.25MBq)

Ro15-4513, tritiated at the 7,9 position. Ro15-4513 is a partial inverse agonist at GABAA receptors.

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NET925250UC 3384.00 EUR
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Overview

Ro15-4513 acts as an antagonist that blocks alcohol binding at GABAA receptors.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET925:

  1. Hadingham, K.L., Wingrove, P.B., Wafford, K.A., Bain, C., Kemp, J. A., Palmer, K. J., Wilson, A.W., Wilcox, A.S., Sikela, J.M., Ragan, C.I. Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. Molecular Pharmacology, December 1993, 44 (6): 1211-1218.
  2. Lüddens H, Killisch I, Seeburg PH. More than one alpha variant may exist in a GABAA/benzodiazepine receptor complex. J Recept Res., 1991, 11 (1-4): 535-51.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 326.3
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Benzodiazepine, GABAA
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi