The Quantum GX microCT system has been replaced by the Quantum GX2 microCT imaging system. Please contact your local representative for further information, or visit the Quantum GX2 product page (Part Number - CLS149276).
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The Quantum GX microCT multispecies imaging system provides high-resolution images at an X-ray dose low enough to enable true longitudinal imaging capability. With scan times as low as 8 seconds, the Quantum GX supports a workflow of up to 30 subjects per hour, with acquisition, reconstruction, and 3D visualization in under one minute. Automate your microCT imaging analysis, reducing time and increasing reproducibility, with our AccuCT™ advanced automated user-friendly bone analysis software. The Quantum GX is the most versatile small animal microCT imaging instrument proven to work in broad range of applications including, oncology, pulmonary and cardiovascular disease, diabetes, orthopedics and dentistry.
MicroCT imaging with the Quantum GX along with PerkinElmer’s other imaging modalities such as optical and PET provides greater insight into biological activity associated with a disease state as well as treatment.
|Imaging Modality||microCT Imaging|
|Product Brand Name||Quantum|
X-ray CT imaging is commonly used for skeletal imaging as bones are densely mineralized tissues with excellent x-ray attenuation properties. In contrast, soft, less dense tissues often prove to be challenging to image due to their lack of sufficient tissue density. Soft tissues such as muscle, blood vessels and internal organs share similar x-ray attenuation characteristics and are not distinguishable under typical CT settings. In order to introduce density that would improve soft tissue contrast, several contrast agents have been developed for use in clinical and preclinical settings.
Osteoarthritis (OA) is the most common form of arthritis and affects a considerable portion of the elderly population. In the U.S., it is estimated that more than 630 million people worldwide have this chronic condition, generally in the knees. OA occurs when the cartilage that cushions the ends of bones within the joints gradually deteriorates, causing synovitis and joint deformation.
The goal of OA research is to identify new therapeutic strategies that could prevent, reduce, halt progression, or repair the existing damage to the joint. Non-invasive in vivo imaging such as microCT is the standard modality for bone research due to its ability to obtain high-resolution images at an x-ray dose low enough as not to harm the animal. This makes microCT ideal for monitoring disease progression and response to treatments in the same animal over time. However, microCT data visualization and analysis can be cumbersome and time consuming. In this application note, we compared standard microCT software and advanced bone software to investigate bone erosion in an OA rat model.
It’s simple: More information means more understanding,For today’s researchers in oncology, infectious diseases, inflammation, neuroscience, stem cells,and other disciplines, there’s an increasing need for in vivo imaging that enables you to visualize,multiple events simultaneously and to extract the maximum amount of information from each,subject – leading to greater biological understanding.,Multimodal imaging enables a better understanding of disease biology. By utilizing in vivo,optimized bioluminescent and fluorescent agents and radioactive probes, researchers can,measure depth, volume, concentration, and metabolic activity, providing a wealth of information,for untangling the mysteries of disease.,Coregistration allows researchers to overlay images from multiple imaging modalities, providing,more comprehensive insight into the molecular and anatomical features of a model subject.,For example, optical imaging data can be used to identify and quantify tumor burden at,the molecular level and, when integrated with microCT, provides a quantitative 3D view of,anatomical and functional readouts.,At PerkinElmer, we’ve developed industry leading imaging technology for preclinical research.,Our technology integrates 3D optical and PET modalities with microCT to provide a better,understanding of disease. And that means better monitoring of disease progression, earlier,detection of treatment efficacy, and deeper understanding of metabolic changes that take place,throughout disease development.
Small animal microCT has been one of the most widely used pre-clinical imaging modalities over much of the last decade. As a result, there has been an ongoing interest in improving resolution while reducing dose to improve imaging capabilities and safety. The Quantum GX is a new imaging instrument that represents the latest such technological advancements. The use of a CMOS flat panel detector enables a combination of high speed and high throughput imaging not previously achievable with earlier generation scanners. The adjustable magnification, in conjunction with the ability to do subvolume reconstruction for higher resolution, also enables a wide range of doses and image resolutions for a variety of animal sizes and applications. It is possible to stitch together images of animals up to the size of a full guinea pig. Furthermore, the fast readout rates that are possible with CMOS technology enable retrospective gating for both respiratory and cardiac imaging, allowing the platform to do both simultaneous and functional CT imaging. These technological advancements are tremendously advantageous for a number of applications. For example, cardiac imaging is often critical in cardiomyopathy studies. As an example we injected Gaq-40 transgenic mice (The Jackson Laboratories) with an intravenous, blood-pooling contrast agent (exitron nano 6000, Miltenyi Biotech). Heart chambers are difficult to clearly see without gating due to motion artifacts, however imaging these mice using a retrospective cardiac image gated protocol readily enabled visualization of heart enlargement. Quantification of heart chamber size indicates that most of the enlargement is seen as a 50-180% increase in right atrium and ventricle size at end diastole.
In vivo micro-computed tomography (micro-CT) imaging of small animals provides three dimensional anatomical maps of the subjects that can be used to study and analyze skeletal bone structures, formation, and diseases. Extracting the bones from raw micro-CT images is a key step in enabling such studies and analyses. While micro-CT images provide contrast between bone and soft tissue components, detecting the bone voxels in a micro-CT volume is challenging considering noise and partial volume effects which result in low voxel density in thin bones such as the pelvis. Furthermore, automated separation of individual bones contained fully or partially in the micro-CT image volume is necessary for performing analysis on different bones and the corresponding cortical and trabecular compartments when manual segmentation is impractical. In this work, a fully automated optimized framework is presented for robust detection, segmentation, and analysis of bones from raw micro-CT images. The imaging platforms used in this work consist of stand-alone Quantum® FX and Quantum® GX micro-CT systems (both by PerkinElmer, Inc.). Small animal data are acquired at different fields of view (5 mm, 10 mm, 24 mm, and 30 mm) and voxel resolutions of 10, 20, 46, and 58 microns for mice and rats in vivo and postmortem. The micro-CT data are converted to Hounsfield units prior to processing and analysis.
High Performance, High Speed, High Resolution microCT imaging with the Quantum GX.,The Quantum GX is the most advanced microCT imaging,system for preclinical research,offering industry leading,resolution combined with high,speed imaging capability at an X-ray dose low enough to enable true,longitudinal imaging of animals. The Quantum GX is the only multispecies,microCT system with the capability to image entire mice, rats and rabbits.,This high resolution, high speed integrated platform enables researchers,to gain a better understanding of disease in a broad range of applications in,cardiovascular, respiratory, bone, lung and brain imaging research.,Gain more insight into the molecular, functional and anatomical readouts,of the experimental model by coregistering of 3D optical data from,PerkinElmer's IVIS® and FMT® platforms with the Quantum GX microCT system,for a better understanding of disease and its progression.
The Xenogen XGI-8 Gas Anesthesia System is designed to work with the IVIS Imaging System, a technology from Xenogen that allows researchers to use r eal-time in vivo imaging to monitor and record cellular and genetic activity within a living organism.
Multimodal co-registration optical, microCT and PET imaging
Gain a better understanding of disease and,its progression with combined high-speed,low-dose x-ray, and high-resolution microCT,imaging in one instrument. The Quantum,GX multispecies microCT imager along with PerkinElmer’s other modalities such as optical and PET,provide greater insight into biological activity associated with a disease state as well as treatment.,The Quantum GX microCT imaging system represents the latest technological advancements,in resolution, speed, and dose reduction to minimize the health impact on research animals during,longitudinal imaging studies. The large bore size (163 mm), adjustable magnification, and wide field,of view (FOV) scanning at 36 mm and 72 mm allows for high resolution imaging of mice, rats,as well as larger animals such as guinea pigs and rabbits. It is possible to stitch together images,of animals up to the size of a guinea pig or rabbit. In addition, this system can acquire images,in either high resolution, high speed or standard modes. In the high resolution mode, a 4.5,µm voxel size resolution can be attained at a 36 mm FOV, while a 9 µm voxel size resolution can be,attained at 72 mm FOV. The ability to perform subvolume reconstruction of larger scans allows,the researcher to perform fine analysis on specific body regions by generating higher resolution,reconstructions of areas of particular interest without having to re-scan the subject. This technical,note highlights some of these features and provides data examples in microCT imaging of small,animal disease models, focusing on both bone imaging as well as the use of contrast agents,for vascular or soft tissue imaging. The Quantum GX’s advanced, yet simple to execute, intrinsic,retrospective two phase gating techniques are ideally suited for animal mo