PerkinElmer
check quantity

PK 11195, [N-Methyl-3H]-, 25µCi (925kBq)

PK-11195, tritiated on the N-methyl group. PK-11195 binds selectively to the peripheral benzodiazepine receptor (PBR).

Please enter valid quantity

Please login to add favorites

NULL OR EMPTY CART

Part Number Unit Size List Price Your Price Quantity
NET885025UC 25 µCi 853.00 EUR
NET885250UC 250 µCi 2814.00 EUR
NET885001MC 1 mCi 6300.00 EUR
Buy Now

You successfully added item(s) to your cart

Overview

PK-11195 acts as an antagonist at peripheral benzodiazepine receptors (PBRs), and is used as a marker of neuronal damage in animal models of central nervous system (CNS) damage. PBRs are potential drug targets for cancer, autoimmune, infectious disease, and neurodegenerative disease.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET885:

  1. V Papadopoulos, P Guarneri, K E Kreuger, A Guidotti, and E Costa. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. PNAS, vol. 89, no. 11, 1992, Pages 5113-5117.
  2. Benavides, J., Quarteronet, D., Plouin, P., Imbault, F., Phan, T., Uzan, A., Renault, C., Dubroeucq, M., Gueremy, C., Le Fur, G. Characterization of peripheral type benzodiazepine binding sites in human and rat platelets by using [3H]PK 11195. Studies in hypertensive patients, Biochemical Pharmacology, vol 33, issue 15, 1984, Pages 2467-2472.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 352.5
Radioisotope H-3
Radionuclide 3H
Receptor Type Benzodiazepine, GABAA
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 25 µCi