PerkinElmer
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Norepinephrine, Levo-[7-3H]-, 5mCi (185MBq)

Levo-Norepinephrine, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).

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Part Number Unit Size List Price Your Price Quantity
NET377250UC 250 µCi 1682.00 EUR
NET377001MC 1 mCi 3683.00 EUR
NET377005MC 5 mCi 12800.00 EUR
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Overview

Norepinephrine (NA) is a neurotransmitter and hormone that increases heart rate and blood pressure, and is involved in the fight-or-flight response. It is widely used to treat low blood pressure.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET377:

  1. Jeannotte, A. M. and Sidhu, A. (2007), Regulation of the norepinephrine transporter by α-synuclein-mediated interactions with microtubules. European Journal of Neuroscience, 26: 1509–1520.
  2. Wersinger, C., Jeannotte, A. and Sidhu, A. (2006), Attenuation of the norepinephrine transporter activity and trafficking via interactions with α-synuclein. European Journal of Neuroscience, 24: 3141–3152.

Specifications

Detection Method Radiometric
Fresh Lot Days This product has a scheduled release date for the third Monday in July.
Label Position Nominally Labeled
Molecular Weight 169.2
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 5 mCi