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Nisoxetine Hydrochloride, [N-Methyl-3H]-, 250µCi (9.25MBq)

Nisoxetine hydrochloride, tritiated on the N-methyl group. Nisoxetine is a potent and selective inhibitor of the norepinephrine transporter.

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NET1084250UC
3175.00 EUR
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Detail Information

Nisoxetine is a selective norepinephrine reuptake inhibitor, and has been used to study obesity. Norepinephrine reuptake inhibitors (NRI, NERI) block the action of the norepinephrine transporter (NET), which is a potential drug target for ADHD and narcolepsy in addition to obesity.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1084:

  1. Tsuruda, P., Yung, J., Martin, W. J., Chang, R., Mai, N., Smith, J.A.M. (2010) Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters. Journal of Pharmacological and Toxicological Methods, 61 (2): 192-204.
  2. Wersinger, C., Jeannotte, A. and Sidhu, A. (2006), Attenuation of the norepinephrine transporter activity and trafficking via interactions with α-synuclein. European Journal of Neuroscience, 24: 3141–3152.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 307.8
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Norephinephrine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Obesity
Unit Size 250 µCi