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Neurotensin, [3,11-Tyrosyl-3,5-3H(N)]-, 25µCi (925kBq)

Neurotensin radioligand tritiated at the 3,5 position of the tyrosine residues. Neurotensin is a neuropeptide that acts as an agonist on the neurotensin receptor family.

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25 µCi
935.00 EUR
250 µCi
4911.00 EUR
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Detail Information

Neurotensin functions as an agonist at neurotensin receptors. It is known to induce analgesia, hypothermia and increased locomotor activity. Neurotensin is also involved in the regulation of dopamine.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET605:

  1. Mohamed Najimi, Alain Sarrieau, Nicolas Kopp, Fatiha Chigr. An autoradiographic strudy of neurotensin receptors in the human hypothalamus. Acta Histochemica. March 2017. Volume 116, Issue 2, pages 282-389.
  2. Su Xiao, Jim F. White, Michael J. Betenbaugh, Reinhard Grisshammer , Joseph Shiloach. Transient and stable expression of the neurotensin receptors NTS1: A comparison of the baculovirus-insect cell and the T-Rex-293 expression systems. PLOS ONE. May 2013.
  3. Jordan A.Mechanic, Janette E. Sutton, Amy E. Berson, Xiaosu Wu, Joyce Kwan, Rudy Schreiber, Zhen Pang, Donald C. Button. Involvement of the neurotensin receptor 1 in the behavioral effects of two neurotensin agonist, NT-2 and NT69L: Lack of hypothermic, antinociceptive and antipsychotic actions in receptor knockout mice. European Neuropsychopharmacology. July 2009. Volume 19, Issue 7, pages 466-475.
  4. Ha Minh Ky Nguyen, Catherine MCahill, Peter S McPherson, Alain Beaudet. Receptor-mediated internalization of [3H]-neurotensin in synaptosomal preparations from rat neostriatum. Neuropharmacology. June 2002. Volume 42, Issue 8, pages 1089-1098.


Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Nominally Labeled
Molecular Weight 1672.9
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Neurotensin
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Pain, Inflammation
Unit Size 25 µCi
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Radiometric Reagents Guide 2010-2011

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