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Neurotensin, [125I]Tyr3], 50µCi

Neurotensin, labeled with 125I on the tyrosine 3 residue. Neurotensin functions as an agonist at neurotensin receptors. It is known to induce analgesia, hypothermia and increased locomotor activity. Neurotensin is also involved in the regulation of dopamine.

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Unit Size
List Price
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NEX198010UC
10 µCi
1238.00 EUR
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NEX198050UC
50 µCi
2588.00 EUR
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX198:

  1. Pettibone, D.J., Hess, J.F., Hey, P.J., Jacobson, M.A., Leviten, M., Lis, E.V., Mallorga, P.J., Pascarella, D.M., Snyder, M.A., Williams, J.B., Zeng, Z. (2003), The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin., J Pharmacol Exp Ther, 300 (1): 305-313.

Specifications

Concentration 88.5 µCi/mL
Detection Method Radiometric
Fresh Lot Days Third Monday of each month
Label Position Nominally Labeled
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Neurotensin
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Pain, Inflammation
Unit Size 50 µCi