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Methyl-4-Phenylpyridinium Acetate, N-[Methyl-3H]-, MPP (+), 250µCi (9.25MBq)

N-Methyl-4-phenylpyridinium (MPP+) acetate, tritiated on the methyl group. MPP+ is a substrate for the organic cation ion transporter (OCT), the dopamine transporter (DAT), the norepinephrine transporter (NET), and the serotonin transporter (SERT).

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Unit Size
List Price
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NET914050UC
50 µCi
720.00 EUR
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NET914250UC
250 µCi
1919.00 EUR
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Detail Information

MPP+ is a dopaminergic selective neurotoxin, and has been used to study Parkinson's disease.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET914:

  1. Kristufek, D., Rudorfer, W., Pifl, C. and Huck, S. (2002), Organic cation transporter mRNA and function in the rat superior cervical ganglion. The Journal of Physiology, 543: 117–134.
  2. Russ, H., Gliese, M., Sonna, J. et al. The extraneuronal transport mechanism for noradrenaline (uptake2) avidly transports 1-methyl-4-phenylpyridinium (MPP+). Naunyn-Schmiedeberg's Arch Pharmacol (1992) 346: 158.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 229.3
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Dopamine Transporter
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi