PerkinElmer
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MK-912, [3H(G)]

MK-912 radioligand. MK-912 acts as a selective antagonist at the α2-adrenoceptor.

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Unit Size
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NET1227025UC
25 µCi
559.00 EUR
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NET1227250UC
250 µCi
4060.00 EUR
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Detail Information

MK-912 functions as a α2-adrenoceptor antagonist. It is used in studies looking at regulation of cardiovascular and CNS functions. This compound replaces NET1059.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1227:

  1. A Drews, J.-J Pietzsch, R Syhe, S Seifert, K Varanas, H Hall, C Halldin, W Kraus, P Karlsson, C Johnsson, H Spies, B Johannsen. Synthesis and biological evaluation of technetium (III) mixed-ligand complexes with high affinity for the cerebral 5-HT1A receptor with the alpha1-adenergic receptor. Nuclear Medicine and Biology. May 2002. Volume 29, Issue 4, page 389-398.

Specifications

Detection Method Radiometric
Label Position Generally Labeled
Molecular Weight 339.4
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Adrenoceptors
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi