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Melatonin, tritiated on the o-methyl group. Melatonin is the endogenous ligand that binds and activates melatonin receptors.

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Part Number List Price Your Price Quantity
NET801250UC 3689.00 EUR
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Melatonin activates melatonin receptors, a group of GPCRs involved in circadium rhythm and reproduction. Melatonin is a hormone that regulates sleep and wakefulness, blood pressure, and seasonal reproduction.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET801:

  1. G. Benítez-King, L. Huerto-Delgadillo, F. Antón-Tay, Binding of 3H-melatonin to calmodulin, In Life Sciences, Volume 53, Issue 3, 1993, Pages 201-207.
  2. G. M. Cahill and J. C. Besharse, Retinal melatonin is metabolized within the eye of xenopus laevis, In PNAS, Volume 86, Issue 3, 1989, Pages 1098-1102.


Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 232.28
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Melatonin
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi