KaryoLite BoBs* has been developed to detect arm-specific aneuploidies in all 24 chromosomes in a single assay for research use only. The product covers p and q arms of all chromosomes 1-22, X and Y (q arms in acrocentric chromosomes).
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KaryoLite BoBs reagents are for Research Use Only. Not for use in diagnostic procedures.
Based on the BACs-on-Beads technology, it consists of BAC DNA immobilized onto polystyrene microspheres distinguishable by the Luminex® instrument system.
KaryoLite BoBs utilizes a new concept of composite beads having DNA from three different BAC clones on each bead type. The composite clone format expands the region of chromosomal DNA interrogated by each bead.
Research may be performed with KaryoLite BoBs using only 50 ng of genomic DNA extracted directly from amniotic fluid, chorionic villae or fetal tissue. As no cell culturing is required with any BoBs assay, KaryoLite BoBs offers a clear advantage over conventional cytogenetic techniques in cases in which cell culture is problematic, for example in POC (product of conception) analysis.
Results in under 24 hours with hands-on time ~ 3 Hours
The probes used have been carefully selected to give information about the whole chromosome including the distal and proximal region of the chromosome arms. For acrocentric chromosomes (13, 14, 15, 21 and 22) three beads have been selected to cover exclusively the q-arms.