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INSULIN (porcine), [125I], 10µCi (370kBq), Specific Activity:80-120µCi (2.96-4.44MBq)/µg

Insulin (porcine), labeled with 125I. Insulin is a peptide hormone that binds to insulin receptors to increase cellular uptake of glucose, increase DNA replication and protein synthesis, and modify enzymatic activity. This product is radioiodinated with 125I using a modification of the Hunter and Greenwood method and purified by ion-exchange column chromatography. This method predominantly labels tyrosine residues.

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NEX104010UC 1026.00 EUR
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Overview

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX104:

  1. Shimazu, T., Borjigin, L., Katayama, Y., Li, M., Satoh, T., Watanabe, K., Kitazawa, H., Roh, S.-g., Aso, H., Kazuo, K., Suda, Y., Sakuma, A., Nakajo, M. and Suzuki, K. (2014), Genetic selection for resistance to mycoplasmal pneumonia of swine (MPS) in the Landrace line influences the expression of soluble factors in blood after MPS vaccine sensitization. Animal Science Journal, 85: 365–373.
  2. Runnels, H.A., Arbuckle, J.A., Bailey, K.S. et al. (2010), Human monoclonal antibodies to the insulin-like growth factor 1 receptor inhibit receptor activation and tumor growth in preclinical studies, Adv Therapy 27: 458-475.

Specifications

Detection Method Radiometric
Fresh Lot Days Second Monday of each month
Label Position Nominally Labeled
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Insulin
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Obesity, Diabetes
Unit Size 10 µCi

Resources, Events & More

Resource Type File Name File Format
Technical Note Low Volume Handling Suggestions for Iodine-125 Labeled Compounds PDF  177 KB
Flyer Using the NENSure Packaging System from PerkinElmer PDF  447 KB