PerkinElmer
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Insulin-like Growth Factor-I (human, recombinant), 25µCi

Insulin-like growth factor 1 (IGF-1), labeled with 125I. IGF-1 acts as an agonist at the IGF-1 receptor, a receptor tyrosine kinase, that plays a role in growth, cancer, and aging. IGF-1 also binds the insulin receptor (IR), another receptor tyrosine kinase involved in glucose homeostasis, diabetes, and cancer.

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Unit Size
List Price
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NEX241005UC
5 µCi
831.00 EUR
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NEX241025UC
25 µCi
2039.00 EUR
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX241:

  1. Takahashi, T., Y. Kobayashi, S. Haga, Y. Ohtani, K. Sato, Y. Obara, A. Hagino, S. G. Roh, and K. Katoh. (2012), A high-protein diet induces dissociation between plasma concentrations of growth hormone and ghrelin in wethers. J. Anim. Sci. 90: 4807-4813.
  2. Runnels, H.A., Arbuckle, J.A., Bailey, K.S. et al. (2010), Human monoclonal antibodies to the insulin-like growth factor 1 receptor inhibit receptor activation and tumor growth in preclinical studies, Adv Therapy, 27: 458-475.

Specifications

Detection Method Radiometric
Fresh Lot Days Third Monday of each month
Label Position Nominally Labeled
Molecular Weight 7773.0
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Insulin-like Growth Factor
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Diabetes, Cancer
Unit Size 25 µCi