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GLP-1 (7-36) (human) LANCE Ultra TR-FRET Detection Kit, 10,000 Assay Points

The LANCE® Ultra Human GLP-1 (7-36) Detection Kit is designed for detection and quantitation of human GLP-1 (7-36) in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

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For research use only. Not for use in diagnostic procedures.

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TRF1215C
500 Assay Points
826.00 EUR
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TRF1215M
10,000 Assay Points
11000.00 EUR
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Detail Information

The LANCE® Ultra Human GLP-1 (7-36) Detection Kit is designed for detection and quantitation of human GLP-1 (7-36) in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

  • No-wash steps, no separation steps
  • TR-FRET technology
  • Sensitive detection
  • High reproducibility
  • Faster time-to-results
  • Easy automation
  • 96-well, 384-well, and 1536-well formats

 

LANCE® and LANCE® (Lanthanide chelate excite) Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One antibody of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and the second molecule is labeled with an acceptor fluorophore (ULight™ dye). Upon excitation at 320 or 340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (~10 nm). This results in the emission of light at 665 nm.

 

The Glucagon-Like Peptide-1 (GLP-1 (7-36 amide)) is a 30-31 oligopeptide, generated from proglucagon, secreted by the enteroendocrine L cells of the small and large intestine, in a nutrient-dependent manner (some GLP-1 (7-36 amide) is also produced by the pancreatic α-cells and in the central nervous system). Circulating GLP-1 (7-36 amide) levels rapidly increase shortly after ingestion, playing a significant role in the inhibition of gastric emptying and food intake. It is also important for blood glucose homeostasis through the stimulation of insulin biosynthesis and secretion, islet proliferation, and the inhibition of glucagon secretion. Moreover, it regulates hypothalamic-pituitary function and GLP-1 activated circuits mediate the central nervous system response to aversive stimulation. In the circulation, the active form of GLP-1 (GLP-1 (7-36 amide)) is promptly inactivated by the dipeptidyl peptidase IV (DP IV).

Specifications

Assay Target GLP-1
Assay Target Class Peptide
Automation Compatible Yes
Detection Method Time-Resolved Fluorescence (TRF), TR-FRET
Experimental Type In vitro
Product Brand Name LANCE Ultra
Shipping Condition Blue Ice
Target Species Human
Therapeutic Area Metabolic
Unit Size 10,000 Assay Points