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Ghrelin (human), [His[125I]], 10µCi

Ghrelin, labeled with 125I. Ghrelin is a peptide that regulates appetite and energy, and binds the ghrelin/growth hormone secretagogue receptor (GHS-R).

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NEX388010UC
10 µCi
1662.00 EUR
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NEX388025UC
25 µCi
3239.00 EUR
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX388:

  1. Gauna, C., van de Zande, B., van Kerkwijk, A., Themmen, A.P., van der Lely, A.J., Delhanty, P.J. (2007), Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R). Mol Cell Endocrinol, 274 (1-2): 30-34.
  2. Leung, P.K., Chow, K.B., Lau, P.N., Chu, K.M., Chan, C.B., Cheng, C.H., Wise, H. (2007), The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor. Cell Signal, 19 (5): 1011-1022.

Specifications

Detection Method Radiometric
Fresh Lot Days Fourth Monday of each month
Label Position Nominally Labeled
Molecular Weight 3495.0
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Ghrelin
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Obesity
Unit Size 10 µCi