Dofetilide, [N-methyl-³H], 100 µCi

Dofetilide acts as a selective potassium channel (hERG) blocker, and is used as an antiarrthythmic drug. The hERG ion channel is involved in the electrical activity of the heart's beating, and is an important antitarget to avoid during drug development.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1144:

1. Steven M. Murphy, Marc Palmer, Michelle Fontilla Poole, Linas Padegimas, Karen Hunady, Joel Danzig, Sikander Gill, Rajwant Gill, Anthony Ting, Bruce Sherf, Kurt Brunden, Alain Stricker-Krongrad, Evaluation of functional and binding assays in cells expressing either recombinant or endogenous hERG channel, In Journal of Pharmacological and Toxicological Methods, Volume 54, Issue 1, 2006, Pages 42-55.