PerkinElmer
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Diltiazem, cis-(+)-[N-Methyl-3H]-, 250µCi (9.25MBq)

cis-(+)-Diltiazem, tritiated at the N-methyl position. Diltiazem is a non-DHP calcium channel blocker.

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Part Number Unit Size List Price Your Price Quantity
NET847250UC 250 µCi 2304.00 EUR
NET847001MC 1 mCi 5200.00 EUR
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Overview

Diltiazem is a nondihydropyridine (non-DHP) calcium channel blocker used to treat hypertension and arrythmia.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET847:

  1. Rupniak, N.M.J., Boyce, S., Williams, A.R., Cook, G., Longmore, J., Seabrook, G.R., Caeser, M., Iversen, S.D. and Hill, R.G. (1993), Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580. British Journal of Pharmacology, 110: 1607–1613.
  2. Hans Schoemaker, Polyamines allosterically modulate [3H]nitrendipine binding to the voltage-sensitive calcium channel in rat brain, In European Journal of Pharmacology: Molecular Pharmacology, Volume 225, Issue 2, 1992, Pages 167-169.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 414.5
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Calcium
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Pain
Unit Size 250 µCi