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Cyclopentyl-1,3-Dipropylxanthine, 8-[Dipropyl-2,3-3H(N)]-, 250µCi (9.25MBq)

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948), tritiated at the dipropyl-2,3- positions. DPCPX acts as a potent and selective antagonist for the adenosine A1 receptor.

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NET974250UC
250 µCi
1830.00 EUR
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NET974001MC
1 mCi
4193.00 EUR
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Detail Information

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948) acts as an antagonist at the adenosine A1 receptor. This receptor is part of a group of adenosine GPCRs, is implicated in sleep promotion and breathing, and is a potential drug target for sleep apnea.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET974:

  1. Schetz, J. A. and Sibley, D. R. (1997), Zinc Allosterically Modulates Antagonist Binding to Cloned D1 and D2 Dopamine Receptors. Journal of Neurochemistry, 68: 1990–1997.
  2. Qinye Dong, Jennifer Schuchman, Gale B. Carey, Characterization of the swine adipocyte A1 adenosine receptor using an optimized assay system, In Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, Volume 108, Issue 3, 1994, Pages 269-280.

Specifications

Detection Method Radiometric
Label Position Nominally Labeled
Molecular Weight 305.4
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Adenosine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Cardiovascular, Inflammation
Unit Size 250 µCi