PerkinElmer
check quantity

CP 55940, [Side Chain-2,3,4-3H(N)]-, 1mCi (37MBq)

CP 55,940, tritiated on the side chain-2,3-4 position. CP 55,940 is a synthetic cannabinoid that acts as a full agonist at both cannabinoid CB1 and CB2 receptors, and can also upregulate serotonin 5-HT2A receptors.

You successfully added item(s) to your cart

Part Number
Unit Size
List Price
Your Price
Quantity
NET1051025UC
25 µCi
941.00 EUR
more
NET1051250UC
250 µCi
2694.00 EUR
more
NET1051001MC
1 mCi
6900.00 EUR
more
Buy Now

Please enter valid quantity

Please login to add favorites

NULL OR EMPTY CART

Detail Information

CP 55,940 is a synthetic cannabinoid that mimics the effects of naturally occuring tetrahydrocannabinol (THC). It acts as a full agonist at cannabinoid receptors type 1 and 2. These GPCRs are potential drug targets for a variety of diseases, including epilepsy, cancer, obesity, and osteoporosis.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1051:

  1. Chiang, Y.-C. and Chen, J.-C. (2007), The role of the cannabinoid type 1 receptor and down-stream cAMP/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized rats. Journal of Neurochemistry, 103: 2505–2517.
  2. Gatch MB, Kozlenkov A, Huang RQ, Yang W, Nguyen JD, González-Maeso J, et al. (2013), The HIV antiretroviral drug efavirenz has LSD-like properties. Neuropsychopharmacology, 38: 2373–2384.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Nominally Labeled
Molecular Weight 376.0
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Cannabinoid
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Angiogenesis, Pain, Cardiovascular, Inflammation, Metabolic Disorders, Gastrointestinal
Unit Size 1 mCi
Resources, Events & More
  • All

Brochure

Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

PDF 2 MB