Designed for fast-paced, high-volume laboratories that need to increase analytical cycle times, the Clarus 690 GC provides superior sensitivity, capacity, and throughput – with flexibility to handle more. Our industry-leading portfolio of TurboMatrix™ options include headspace (HS), manual and automated thermal desorption (TD, ATD) and MultiPrep Autosampler solutions.
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When the highest levels of throughput are critical to your operations, choose the Clarus 690 gas chromatograph. Its patented high-performance oven delivers the fastest heat-up and cool-down of any oven in the business, and that means shorter injection-to-injection times, and the ability to run more samples per day. Plus, the oven’s twin-wall design with concentric air exhaust provides exceptional cooling to near-ambient temperatures without resorting to liquid cryogen – critical for analysis of VOCs. The Clarus 690 GC features a wide-range flame ionization detector (FID), a new high-performance capillary injector with decreased reactivity, and autosampler technology that delivers multiple options for liquid injection, headspace, and SPME on one system.
This system is driven by our TotalChrom™ chromatography data system (CDS) that serves as both an instrument controller and a data management system, making it the best choice for data handling in demanding multiuser, multisite environments where a number of instruments are in use. Plus, the TotalChrom system’s unique data protection features ensure that data acquisition processes aren’t disrupted or compromised. Plus, our GC instruments feature an intuitive touch-screen interface with real-time signal display and eight-language support for greatly simplified user interaction.
The purpose of this app note is to apply novel oven technology, a short GC column and high oven heating and cooling rates to a modified 8015 DRO method.
EPA Method TO-17 is used to determine toxic compounds in air after they have been collected onto sorbent tubes. These tubes can either adsorb specific compounds or adsorb a broad range of compounds, quantitatively. Adsorbent tubes have many applications in the investigation of volatile organic compounds (VOCs) found in EPA Method TO-17. Examples include indoor air, fence line, stack, workplace, personal monitoring and soil gas. The type of tube used, and whether the sampling is passive or active, depends upon the need at the particular site being investigated. ,This application note demonstrates that the PerkinElmer TurboMatrix™ Thermal Desorber and the PerkinElmer Clarus® SQ 8 GC/MS will meet and exceed the criteria set forth in EPA method TO-17. Detailed instrument method parameters are presented, with precision, recovery, linearity and detection limit results.
Although considered pharmacologically inert, pharmaceutical excipients have been shown to interact with active drug substances to affect the safety and efficacy of drug products.1 Therefore, there is an increasing awareness of the necessity to understanding interactions between excipients and the active pharmaceutical ingredient (API) in finished dosage forms. One of the areas of major concern is the potential chemical interaction between impurities in the excipient with the drug molecules, leading to formation of reaction products. Even trace amounts of reactive impurities can cause significant drug stability problems as the quantity of excipients in a formulation often far exceeds that of an API on a weight and molar basis. Trace amounts of reaction products can then easily exceed 0.2% qualification thresholds for a degradation in many drug products. Formaldehyde present in excipients has been implicated in the degradation of several drug products where it can form adducts with primary and/or secondary amine groups.2 It has also been reported that formaldehyde can induce cross-linking in gelatin capsules causing an adverse effect on in-vitro dissolution rates of drugs. Because of the extremely high reactivity of aldehydes, a timely evaluation of their presence in excipients during formulation design is essential to avoid unexpected drug stability problems in later stages of product development.
Furan is naturally occurring at low levels in many foods and drinks. Furan consumption is of concern because it been classified by IARC as possibly carcinogenic to humans, based on studies in laboratory animals.
The existing ASTM® D4815 method is designed to monitor oxygenated compounds in gasoline at percentage concentrations. The method described in this application note is intended to enable these analytes to be monitored down to low-ppm concentrations.
ASTM® D7059-04 is an established method that has been well validated for the determination of methanol in crude oils. In this application note, a method based on a PerkinElmer® Clarus® 600 GC with an S-Swafer™ splitting device is described.
ASTM® methods used for simulated distillation (SimDist) applications have been widely used to obtain reliable and repeatable analysis given the specific parameters of each method. PerkinElmer has enhanced three popular ASTM® methods (D2887, D6352, and D7169).
The contamination of aviation fuel with fatty acid methyl esters (FAMEs) can arise due to the use of multi-product pipelines for fuel supply and distribution. This application note demonstrates the use of the Clarus 600 GC/MS to identify and determine the contamination.
The rapid development of natural ,gas from unconventional sources in ,North America has created an energy ,“gold rush” not seen in contemporary ,times. The advent of horizontal drilling ,technologies and hydraulic fracturing has ,made this production economical and ,presents an energy source of sufficient ,magnitude that could last 100 years.
The use of Food Contact Materials (FCM) can potentially be detrimental to human health. In the PerkinElmer quantification of Phthalate Leaching from FCMs, using the Clarus GC/MS, we explore how to quantify FCMs.
This application note describes a method that is based on the original ASTM® D-3606 method with the main difference being that capillary columns are used. This approach completely eliminated all chromatographic interference from the ethanol (even solutions made up in pure ethanol could be run), improved the quality of the chromatography in general and reduced the analysis time significantly (by 50% or 75% depending on the column set).
The determination of light hydrocarbons in refinery and other gases is typically performed through the use of packed columns and mechanical rotary valves. For example ASTM Method D-2597 adopts this approach. A gas sampling valve delivers a small metered quantity of the sample gas into a non-polar packed column. The C1 to C5 hydrocarbons are allowed to elute from this column and into a second packed column with a polar stationary phase. At that point a rotary valve is actuated to reverse the flow of carrier gas through the precolumn and backflush any residual sample in that column to a detector to determine the total C6+ content in the sample. In the meantime, chromatography of the C1 to C5 content proceeds on the second column for separation, identification and quantification. The whole analysis takes about 20 minutes and getting acceptable chromatographic separation is often a challenge because of normal variations in the columns. In this application note, a new method is described for this analysis that uses a Swafer™ backflushing technology with capillary columns under isothermal conditions to both improve the chromatographic separation and to reduce the analysis cycle time to just over 5 minutes.
ASTM® Test Method, D2427-06, is designed to determine the C2 to C5 hydrocarbon content in gasolines. This method validates gasoline samples that are depentanized using ASTM® method D2001-07. These samples are intended for functional group hydrocarbon analysis by mass spectrometry according ASTM® Test Method D2789-95 (2005).
The Deepwater Horizon oil spill has contaminated parts of the Gulf of Mexico and estuaries in several coastal states in the southern region of the US.
Headspace Gas Chromatography—for applications involving the solvent-free extraction of volatile compounds, it’s an unsurpassed technique, eliminating the time-consuming steps and risk of human error associated with other GC sample-preparation methods.
This report shows an example of three general degradation processes. The analytical system consisted of a Clarus GC/MS interfaced with a Pyrolysis Autosampler. Samples are rapidly pyrolyzed, automatically introduced into the GC carrier stream
Poster summarizing solutions of thermal analysis, molecular spectroscopy, chromatography and hyphenated techniques for polymers focused on providing more insight into product performance and process optimization that make easier
With the new TurboMatrix MultiPrep+ and TurboMatrix MultiPrep autosamplers, PerkinElmer offers more choices than ever before to help you optimize the workflow of your gas chromatography instrument and maximize the throughput of your lab.
Human civilization has played a leading role in creating massive amounts of greenhouse gas
This white paper discusses the role of System Suitability Tests (SSTs) in the context of Analytical Instrument Qualification (AIQ) and is based upon; the United States Pharmacopoeia (USP) general chapter 1058 on AIQ.