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Chromium-51 Radionuclide, 10mCi (370MBq), Sodium Chromate in Normal Saline (pH 8-10), Steri-packaged

Chromium-51 (51Cr) radionuclide, commonly used as a label for target cells in chromium release assays, cell-mediated cytotoxicity studies, antibody-dependent cytotoxicity (ADCC) studies, and CAR-T cell development. Target cells uptake 51Cr radionuclide, and release the nuclide into the culture media upon cytolysis or cell death.

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Unit Size
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NEZ030S001MC
1 mCi
337.00 EUR
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NEZ030S002MC
2 mCi
418.00 EUR
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NEZ030S005MC
5 mCi
530.00 EUR
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NEZ030S010MC
10 mCi
685.00 EUR
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Detail Information

Chromium-51 is the most commonly used readioactive marker for the labeling of target cells in cytotoxicity assays. The common name for such assays Chromium Release also describes the fundamental method behind the assay procedure. Methods for the precise and accurate quantification of cytotoxicity are of fundamental importance in immunology particularly for the study of tumor and virus cytolysis.
Cytotoxicity assays can be used in order to study either the defense mechanism in a specific patient or to study target cells, depending on whether the effector (or killer) cells are the unknowns. It can also be used for the study of certain drugs on the immune system.
Chromium fulfills the requirement of a good label. It is generally non-toxic (as Na2CrO4), it is easily taken up by the cells, it is spontaneously released only in relatively small amounts, its detection is easy and sensitive and it does not change the morphology and characteristics of the target cell.

Specifications

Concentration 1 mCi/mL
Detection Method Radiometric
Fresh Lot Days Every other Friday
Half Life 27.71 days
Label Position Specifically Labeled
Radioisotope Cr-51
Radionuclide 51Cr
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Unit Size 10 mCi