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CGS 21680, [Carboxyethyl-3H(N)]-, 1mCi (37MBq)

CGS 21680, tritiated at the carboxyethyl group. CGS 21680 acts as an agonist for the adenosine A2A receptor, but can also bind adenosine A1 and A3.

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NET1021250UC
250 µCi
2577.00 EUR
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NET1021001MC
1 mCi
6200.00 EUR
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Detail Information

CGS 21680 is an agonist for the adenosine A2A receptor. Adenosine A2A receptors are GPCRs that regulate myocardial blood flow as well as glutamate and dopamine release in the brain. These receptors are potential drug targets for insomnia, pain, depression, drug addiction, and Parkinson's disease.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1021:

  1. Varani, K., Gessi, S., Dalpiaz, A. and Borea, P. A. (1996), Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding. British Journal of Pharmacology, 117: 1693–1701.
  2. Michael F. Jarvis, Michael Williams, Direct autoradiographic localization of adenosine A2 receptors in the rat brain using the A2-selective agonist, [3H]CGS 21680, In European Journal of Pharmacology, Volume 168, Issue 2, 1989, Pages 243-246.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Nominally Labeled
Molecular Weight 499.53
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Adenosine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Cardiovascular, Inflammation, Metabolic Disorders
Unit Size 1 mCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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