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AH5183, L-[PIPERIDINYL-3,4-3H]-(VESAMICOL), 250 µCi

AH5183 (vesamicol) radioligand tritiated at the piperidinyl-3,4 position. AH5183 is an acetylcholine transport blocker.

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NET964250UC
1351.00 EUR
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Detail Information

AH5183 (vesamicol, (2-hydroxyethyl)-1-piperazine-ethanesulfonic acid, (4-phenylpiperidino) cyclohexanol) is a cholinergic vesicular uptake blocker. Vesicular acetylcholine transporters (VAChT) are neurotransmitter transporters involved in acetylcholine secretion. Vesamicol inhibits the transport of acetylcholine into synaptic vesicles in nerve terminals, and play a role in drug response and vulnerability to drug addiction.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET964:

  1. Ojeda A.M., Bravo D.T., Hart T.L., Parsons S.M. (2003) Equilibrium Binding and Transport Studies. In: Yan Q. (eds) Membrane Transporters. Methods in Molecular Biology, vol 227. Humana Press.

Specifications

Concentration 1.0 - 10 µCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Vesicular Amine Transporters (VATs)
Shipping Condition Blue Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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