PerkinElmer
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Acetylcholine Iodide, [acetyl-3H], 1mCi (37MBq)

Acetylcholine (Ach) radioligand tritiated on the acetyl group. Acetylcholine is a neurotransmitter and the endogeous ligand that binds to and activates muscarinic and nicotinic acetylcholine receptors.

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NET113001MC
869.00 EUR
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Detail Information

Acetylcholine (ACh) is a neurotransmitter and the endogenous ligand that binds and activates both muscarinic and nicotinic acetylcholine receptors. Muscarinic acetylcholine receptors (mAChRs) are GPCRs that play a role in the parasympathetic nervous system. Nicotinic acetylcholine receptors respond to neurotransmitters and are found in the central and peripheral nervous system, muscle and other tissues and are involved in muscle contraction. Muscarinic acetylcholine receptors are potential targets for Alzheimer disease and glaucoma. Nicotinic acetylcholine receptors have been identified as potential drug targets for Alzheimer's disease, schizophrenia, ADHD, and nicotine addiction.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET113:

  1. Ojeda A.M., Bravo D.T., Hart T.L., Parsons S.M. (2003) Equilibrium Binding and Transport Studies. In: Yan Q. (eds) Membrane Transporters. Methods in Molecular Biology, vol 227. Humana Press.
  2. Harfstrand, A., Adem, A., Fuxe, K., Agnati, L., Andersson, K. and Nordberg, A. (1988), Distribution of nicotinic cholinergic receptors in the rat tel- and diencephalon: a quantitative receptor autoradiographical study using [3H]-acetylcholine, [α-125l]bungarotoxin and [3H]nicotine. Acta Physiologica Scandinavica, 132: 1–14.

Specifications

Label Position Specifically Labeled
Molecular Weight 273.1
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Pain, Inflammation, Metabolic Disorders, Gastrointestinal
Unit Size 10 µCi