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5-HYDROXY TRYPTAMINE, [3H]-

5-hydroxytryptamine (5-HT, or serotonin) labeled with tritium. It is a naturally occurring neurotransmitter which is tied to positive mood, certain involuntary muscle control, and countless other functions.

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Part Number Unit Size List Price Your Price Quantity
NET1167250UC 250 µCi 865.00 EUR
NET1167001MC 1 mCi 3172.00 EUR
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Overview

5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in the central nervous system (CNS). 5-HT binds 5-HT serotonin receptors to regulate smooth muscle in the cardiovascular system and the GI tract and enhances platelet aggregation. These receptors are part of a group of serotonin G-protein coupled receptors (GPCRs) found in the central and peripheral nervous systems. 5-HT receptors are the pharmacological target of many antidepressants, antipsychotic, anti-migraine, and other pharmaceutical drugs.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1167:

  1. Derek N. Middlemiss, John R. Fozard, 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site, In European Journal of Pharmacology, Volume 90, Issue 1, 1983, Pages 151-153.
  2. Derek N. Middlemiss, Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol, In European Journal of Pharmacology, Volume 101, Issues 3–4, 1984, Pages 289-293.
  3. Piñeyro Graciela, Castanon, Nathalie, Hen, René, Blier, Pierre, Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice, NeuroReport, Volume 7, Issue 1, 1995, Pages 353-359.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Generally Labeled
Molecular Weight 290.0
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type 5-Hydroxytryptamine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi

Resources, Events & More

Resource Type File Name File Format
White Paper [Phenyl-3,5-3H] L-Kynurenine PDF  342 KB