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Iodo-(-)-Cyanopindolol, [125I], 500µCi (18.5MBq)

Iodo-(-)-cyanopindolol, labeled with 125I. Cyanopindolol acts as an antagonist at β1 adrenergic receptors and serotonin 5-HT1A receptors.

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Unit Size
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NEX189100UC
100 µCi
1335.00 EUR
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NEX189500UC
500 µCi
2179.00 EUR
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX189:

  1. Houseknecht, K., Bauman, D., Carey, G., Mersmann, H., (1995), Effect of bovine somatotropin and food deprivation on β-adrenergic and A1 adenosine receptor binding in adipose tissue of lactating cows, Domestic Animal Endocrinology, 12 (4): 325-336.
  2. Mersmann, H., McNeel, R., Morkeberg, J., Shparber, A., Hachey, D., (1992), β-Adrenergic Receptor-Mediated Functions in Porcine Adipose Tissue Are Not Affected Differently by Saturated vs. Unsaturated Dietary Fats, The Journal of Nutrition, 122 (10): 1952–1959.

Specifications

Fresh Lot Days First Monday of each month
Label Position Nominally Labeled
Molecular Weight 411.0
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Adrenoceptors
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 500 µCi