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(+/-)Epibatidine, [5,6-Bicycloheptyl-3H]-, 250µCi (9.25MBq)

(+/-)-Epibatidine radioligand tritiated at the 5,6-biocycloheptyl position. Epibatidine has analgesic activities, has been shown to function as an agonist at nicotinic acetylcholine receptors, and has been shown to bind muscarinic and serotonin 5-HT3 receptors.

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Part Number Unit Size List Price Your Price Quantity
NET1102025UC 25 µCi 2423.00 EUR
NET1102250UC 250 mCi 5800.00 EUR
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Overview

Epibatidine is a high affinity agonist of nicotonic acetylcholine receptors and has also been shown to bind muscarinic receptors. These receptors are part of a group of acetylcholine G-protein coupled receptors (GPCRs) found in the central and peripheral nervous system that play a role in neuotransmission. Epibatidine functions as an analgesic at nicotinic receptors.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1102:

  1. A. Lilja, O. Porras, E. Storelli, A. Nordberg, A. Marutle. Functional interactions of fibrillar and oligomeric amyloid-β with α7 nicotinic receptors in Alzheimer’s disease, In Journal of Alzheimer's disease, Volume 23, 2011, Pages 335-47.
  2. A.V. Terry, D.A. Gearhart, S.P. Mahadik, S. Warsi, J.L. Waller, Chronic treatment with first or second generation antipsychotics in rodents: Effects on high affinity nicotinic and muscarinic acetylcholine receptors in the brain, In Neuroscience, Volume 140, Issue 4, 2006, Pages 1277-1287.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 208.7
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Nicotinic
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Pain, Inflammation
Unit Size 250 mCi