PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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Radionuclide
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Radioisotope
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Receptor Type
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"Receptor Ligand Binding" 1-50 of 545 Products and Services

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UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

Iodo-Melatonin, 2-[125I]

Melatonin, labeled with 125I. Melatonin binds and activates melatonin receptors, a class of GPCRs that are potential drug targets for circadian rhythm sleep disorders and depression.
Price Range : 1217.00 EUR - 3076.00 EUR
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 6, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
List Price : 1432.00 EUR

Bombesin (6-14), D-Tyr6[125I]

Bombesin (6-14), labeled with 125I. Bombesin binds and activates bombesin receptors BBR1, BBR2, and BBR3, and is a tumor marker for lung cancer, gastric cancer, pancreative cancer, and neuroblastoma.
Price Range : 1562.00 EUR - 2937.00 EUR
PerkinElmer

ProfilerPro Kinase Peptide Substrate 16, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 16 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 665.00 EUR
PerkinElmer

Membrane Target Systems: Calcitonin CGRP1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR

Rosiglitazone, DL- [3H]-

Tritiated DL-Rosiglitazone (Avandia). Rosiglitazone acts as a selective agonist at peroxisome proliferator-activated receptors (PPARs).
List Price : 1977.00 EUR

MK-801, (+)-[3-3H]-

(+)-MK-801 radioligand tritriated at the 3 position. MK-801 acts as a non-competitive antagonist at the glutamate receptor, N-Methyl-D-aspartate (NMDA).
Price Range : 913.00 EUR - 6400.00 EUR
PerkinElmer

Membrane Target Systems: Transporter Serotonin (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Transporter Serotonin receptor, in HEK-293 cells.
List Price : 823.00 EUR
PerkinElmer

WGA PS 2G Imaging Bead

WGA-coated SPA beads, for capturing cell membranes in proximity-based scintillation assays.
List Price : 1637.00 EUR
Receptor-expressing cell lines

ValiScreen Somatostatin sst5 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Chemokine XCR1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR

Urotensin II (human), [125I]Tyr9

Urotensin II, labeled with 125I. Urotensin II is a vasoconstrictor that binds the urotensin-II receptor.
Price Range : 1863.00 EUR - 2910.00 EUR

Acetylcholine Iodide, [acetyl-3H], 1mCi (37MBq)

Acetylcholine (Ach) radioligand tritiated on the acetyl group. Acetylcholine is a neurotransmitter and the endogeous ligand that binds to and activates muscarinic and nicotinic acetylcholine receptors.
List Price : 869.00 EUR

Ω-Conotoxin MVIIC, [125I]

Ω-Conotoxin MVIIC (ω-Conotoxin MVIIC), labeled with 125I. Ω-Conotoxin MVIIC is a neurotoxin that blocks calcium channels.
Price Range : 914.00 EUR - 2402.00 EUR

[125I]- Epidermal Growth Factor (human, rat)

NEX428 Epidermal Growth Factor is radioiodinated with no carrier added 125I using a lactoperoxidase procedure and is purified by reversed phase HPLC.
Price Range : 892.00 EUR - 1969.00 EUR

NAAG, [Glutamate-3,4-3H]

NAAG radioligand tritiated at the 3,4 position. NAAG is a peptide neurotransmitter that activates the metabotropic glutamate receptor type 3.
Price Range : 1821.00 EUR - 3971.00 EUR
Receptor-expressing cell lines

ValiScreen Adrenergic alpha 2B (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Histamine H2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR
Receptor-expressing cell lines

ValiScreen Somatostatin sst3 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Epibatidine, ([125I]-IPH), [125I]

Epibatidine, labeled with 125I. Epibatidine has analgesic activities, has been shown to function as an agonist at nicotinic acetylcholine receptors, and has been shown to bind muscarinic and serotonin 5-HT3 receptors.
Price Range : 2238.00 EUR - 4907.00 EUR

COUMARIN, 7-ETHOXY, [3- 14C]-

50 µCi quantities of 7-ETHOXY-[3-14C]-Coumarin are available for your research.
List Price : 2734.00 EUR
PerkinElmer

ProfilerPro Kinase Peptide Substrate 18, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 18 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 665.00 EUR

GBR 12935, [Propylene-2,3-3H]

GBR 12935, tritiated at the propylene-2,3 position. GBR 12935 is a piperazine derivative that acts as a selective dopamine reuptake inhbitor.
Price Range : 3002.00 EUR - 8500.00 EUR
PerkinElmer

Membrane Target Systems: Melanocortin MC5 (mouse) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR

SR141716A, [3H]

Tritiated SR141716A (rimonabant; Acomplia; Zimulti). SR141716A acts as an inverse agonist at the cannabinoid CB1 receptor.
List Price : 3492.00 EUR

Kainic acid, [Isopropenyl-3H]

Kainic acid, tritiated on the isoproprenyl group. Kainic acid acts as an agonist at kainate glutamate receptors.
Price Range : 799.00 EUR - 7400.00 EUR
PerkinElmer

Membrane Target Systems: Adrenergic beta 3 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR

Recombinant Protein A, [125I]

Recombinant Protein A, labeled with 125I. I-125 labeled Protein A can be used as a general tracer to capture antibodies in radioimmunoassays (RIAs).
Price Range : 956.00 EUR - 1547.00 EUR
PerkinElmer

ProfilerPro Kinase Peptide Substrate 27, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 27 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 665.00 EUR
PerkinElmer

p53 Acetylated Peptide, for LabChip EZ Reader

Fluorescently-labelled p53 Peptide (Acetylated) for Epigenetic Assays (Enzyme inhibiton, target discovery, lead optimization)
List Price : 544.00 EUR

Apelin 13 [125I]

Apelin, labeled with 125 I. Apelin is the endogenous ligand for apelin receptors, and is used in receptor binding studies. Apelin 13 is a 13-amino acid peptide corresponding to residues 65-77.
Price Range : 1229.00 EUR - 4282.00 EUR
Receptor-expressing cell lines

Chemokine CCR1 ValiScreen Cell Line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

ValiScreen Prostanoid DP (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Histamine Dihydrochloride, [Ring, Methylenes-3H(N)]

Histamine dihydrochloride, tritiated on the ring and methylene groups. Histamine is an endogenous agonist of histamine receptors.
Price Range : 1519.00 EUR - 3305.00 EUR
PerkinElmer

Membrane Target Systems: Vasopressin V2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human Vasopressin V2 receptor, 400 units.
List Price : 823.00 EUR
Receptor-expressing cell lines

ValiScreen Purinergic P2Y2 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Ro 15-1788, [N-Methyl-3H]

Ro 15-1788 (flumazenil), tritiated on the N-methyl group. Ro 15-1788 acts as a selective benzodiazepine antagonist.
Price Range : 913.00 EUR - 6800.00 EUR
Receptor-expressing cell lines

ValiScreen Histamine H1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Colchicine, [ring C, Methoxy-3H]-, 250µCi (9.25MBq)

Colchicine, tritiated at the ring C methoxy- position. Colchicine binds tubulin to prevent microtubule polymerization, and is used to treat gout.
List Price : 2471.00 EUR

Adenosine 3',5'-cyclic Phosphoric Acid, 2`-O-succinyl [125I]-Iodotyrosine Methyl Ester

cAMP, labeled with 125I on the tyrosine methyl ester group. I-125 labeled cAMP can be used as a tracer for radioimmunoassays to detect levels of endogenous cAMP in a sample or for GPCR functional assays.
Price Range : 466.00 EUR - 5700.00 EUR

Cyclopentyl-1,3-Dipropylxanthine, 8-[Dipropyl-2,3-3H(N)]

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948), tritiated at the dipropyl-2,3- positions. DPCPX acts as a potent and selective antagonist for the adenosine A1 receptor.
Price Range : 1830.00 EUR - 4193.00 EUR
PerkinElmer

PDE YSI 500MG

SPA (scintillation proximity assay) beads designed for the capture of [3H]AMP or [3H]GMP on specially prepared yttrium silicate beads.
List Price : 760.00 EUR
PerkinElmer

Membrane Target Systems: Serotonin 5HT-2C (ne) (human) membrane preparation, in 1321N1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR

"Receptor Ligand Binding" 1-50 of 545 Products and Services

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