PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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Product Type
  • Consumables (2)
  • Instruments (7)
  • Reagents (536)
Target Species
  • Human (10)
Application
  • cAMP (26)
  • Drug Discovery & Development (335)
  • Mobility Shift (36)
  • Plant Sciences (1)
  • Protein Analysis & Detection (5)
  • Protein-protein interactions (4)
  • Radiometric (4)
Therapeutic Area
  • Angiogenesis (27)
  • Biologics/Bioprocess (2)
  • Cancer (21)
  • Cardiovascular (117)
  • Central Nervous System (97)
  • CNS & Neurologic (122)
  • Diabetes (20)
  • Gastrointestinal (75)
  • Immune (3)
  • Inflammation (135)
  • Metabolic (51)
  • Metabolic Disorders (41)
  • Musculoskeletal (1)
  • Obesity (9)
  • Pain (69)
  • Parasympathetic Nervous System (5)
  • Renal (2)
  • Sympathetic Nervous System (2)
Product Brand Name
  • AequoScreen (4)
  • AequoZen (5)
  • AlphaLISA (3)
  • cAMPZen (1)
  • DELFIA (4)
  • LabChip EZ Reader (50)
  • Membrane Target Systems (112)
  • MicroBeta (2)
  • NEN Radiochemicals (113)
  • NEN Radiolabeled Ligands (75)
  • OmniFilter (1)
  • SPA Imaging Beads (18)
  • SPA Scintillation Beads (26)
  • UniFilter (7)
  • ValiScreen (77)
Color
  • White (4)
Coating Treatment
  • Anti-mouse antibody (2)
  • Anti-mouse IgG (2)
  • Anti-rabbit antibody (2)
  • Anti-rabbit IgG (2)
  • Copper (HIS-tag) (2)
  • Copper chelate (2)
  • Glutathione (4)
  • HIS (2)
  • Nickel chelate (HIS-tag) (2)
  • PDE (2)
  • PEI (14)
  • Poly-L-lysine (2)
  • Poly-lysine (5)
  • Protein A (2)
  • RNA Binding (1)
  • Streptavidin (13)
  • Uncoated (1)
  • WGA (17)
  • WGA PEI type A (1)
  • WGA PEI Type B (1)
Material
  • Barex/GF/B (1)
  • Barex/GF/C (1)
  • Polystyrene/GF/B (1)
  • Polystyrene/GF/C (1)
Detection Method
  • Alpha (3)
  • DELFIA TRF (4)
  • Filtration (4)
  • Fluorescence (1)
  • Radiometric (248)
  • Time-Resolved Fluorescence (TRF) (4)
Receptor Type
  • 5-Hydroxytryptamine (12)
  • 5-Hydroxytryptamine (Serotonin) (23)
  • Acetylcholine (1)
  • Acetylcholine (Muscarinic) (16)
  • Adenosine (14)
  • Adrenergic (13)
  • Adrenoceptors (10)
  • Anaphylatoxin (4)
  • Angiotensin (9)
  • Apelin (2)
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  • Bombesin (5)
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  • Cannabinoid (8)
  • Chemokine (15)
  • Cholecystokinin (5)
  • Corticotropin-Releasing Factor (1)
  • Dopamine (19)
  • Dopamine Transporter (2)
  • Endothelin (3)
  • Epidermal Growth Factor (2)
  • Formyl Peptide (2)
  • Free Fatty Acid (2)
  • GABA (4)
  • GABAA (6)
  • GABAB (1)
  • Galanin (5)
  • Ghrelin (4)
  • Glucagon (6)
  • Glutamate (7)
  • Glycine (4)
  • Gonadotropin-releasing Hormone (1)
  • Growth Hormone (1)
  • hERG (3)
  • Histamine (9)
  • Insulin (3)
  • Insulin-like Growth Factor (1)
  • Interleukin (1)
  • Leukotriene (3)
  • Melanin-Concentrating Hormone (1)
  • Melanocortin (12)
  • Melatonin (4)
  • Metastin (1)
  • Motilin (1)
  • Muscarinic (10)
  • Neuromedin U (2)
  • Neuropeptide (7)
  • Neuropeptide Y (3)
  • Neurotensin (5)
  • Nicotinic (8)
  • NMDA (1)
  • Norephinephrine (1)
  • Norepinephrine (2)
  • Opioid (25)
  • Orexin (4)
  • Oxytocin (2)
  • Peptide P518 (1)
  • Platelet-Derived Growth Factor (1)
  • Potassium (2)
  • Progestin (1)
  • Prokineticin (1)
  • Prolactin Releasing Peptide (2)
  • Prostanoid (8)
  • Purinergic P2Y (2)
  • Relaxin (3)
  • Retinoic Acid Receptors (1)
  • Serotonin (4)
  • SK channels (1)
  • Somatostatin (11)
  • SVCT1 (1)
  • SVCT2 (1)
  • Tachykinin (7)
  • Thyroid Hormone (3)
  • Thyrotropin Releasing Hormone (1)
  • Thyrotropin-releasing Hormone (2)
  • Transforming Growth Factor (1)
  • TRPC5 (1)
  • Urotensin (2)
  • Vasoactive Intestinal Peptide (3)
  • Vasopressin (12)
  • Vesicular Amine Transporters (VATs) (1)
Assay Validated
  • Binding (211)
  • Calcium Fluorescence (21)
  • Calcium Luminescence (9)
  • cAMP (56)
  • Downstream Phosphorylation (1)
  • GTPγS (52)
  • Inositol Phosphate (15)
Sample Type
  • Enzyme (38)
Radioisotope
  • C-14 (6)
  • H-3 (109)
  • I-125 (77)
  • S-35 (1)
Radionuclide
  • 125I (77)
  • 14C (5)
  • 35S (1)
  • 3H (1)
  • 3H (108)
Fluorophore
  • Eu-N1-ITC (2)
Label Position
  • Generally Labeled (6)
  • Nominally Labeled (96)
  • Specifically Labeled (90)
  • Uniformly Labeled (1)
Assay points(200-50,000)
  • 500 (2)
  • 5000 (2)
Assay Target Class
  • GPCR (186)
  • Ion channel (2)
  • Transporter (6)
  • Tyrosine Kinase Receptor (1)
Automation Compatible
  • No (20)
  • Yes (50)
Concentration
  • 1 mCi/mL (3)
  • 1.0 - 10 mCi/mL (57)
  • 1.0 - 10 µCi/mL (3)
  • 1.12 mCi/mL (1)
  • 1.14 mCi/mL (1)
  • 152 µCi/mL (1)
  • 170.1 µCi/mL (1)
  • 171 µCi/mL (1)
  • 172.5 µCi/mL (1)
  • 173.9 µCi/mL (1)
  • 182 µCi/mL (2)
  • 2.93 MBq/mL (1)
  • 236 µCi (1)
  • 3.06 MBq/mL (1)
  • 3.22 MBq/mL (1)
  • 33.7 µCi (1)
  • 345 µCi/mL (3)
  • 353 µCi/mL (3)
  • 41.4 µCi/mL (2)
  • 42.5 µCi/mL (1)
  • 45.7 µCi/mL (1)
  • 50 µCi/mL (1)
  • 6.05 MBq/mL (1)
  • 79.2 µCi/mL (2)
  • 83.8 µCi/mL (1)
  • 85.1 µCi/mL (1)
  • 87.2 µCi/mL (1)
  • 87.4 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • 87.9 µCi/mL (1)
  • 88.5 µCi/mL (1)
  • 93.2 µCi/mL (1)
  • <1.0 mCi/mL (7)
  • <1.0 µCi/mL (3)
  • <100 µCi/mL (1)
Experimental Type
  • In vitro (4)
Format
  • Microplates (19)
  • Tubes (11)
Host Cell
  • 1321N1 (11)
  • A431 (1)
  • A9 (1)
  • CHO-DHFR(-) (1)
  • CHO-K1 (137)
  • HEK293 (41)
  • HT29 (1)
  • K562 (1)
  • L Cells (1)
  • MDA-MB-435S (1)
  • MDCK (2)
  • U373 (1)
  • UC11 (1)
Length
  • 51-100 (6)
Number of Wells
  • 96 (4)
Pipetting Arms
Volume
  • 0-50 (44)
  • 51-100 (1)
  • 201-250 (56)

"Receptor Ligand Binding" 1-50 of 545 Products & Services

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LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.
Receptor-expressing cell lines

ValiScreen Adenosine A2b (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Alpha Bungarotoxin

IL-6 (human, recombinant), [125I]

Interleukin 6 (IL-6), labeled with 125I. IL-6 is a cytokine that regulates cell growth, cell differentiation, and immune response, and binds to the interleukin 6 receptor (IL6R; CD126).
Price Range : 1747.00 EUR - 5800.00 EUR
Adenosine 5 Triphosphate 250 µCi

SR 95531, [Butyryl-2,3-3H]-, 250µCi (9.25MBq)

SR-95531 (Gabazine), tritiated at the butyryl-2,3 position. SR-95531 acts as an antagonist at GABAA receptors.
List Price : 4843.00 EUR
Receptor-expressing cell lines

ValiScreen Somatostatin sst1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

DELFIA Eu-Labeling kit (Eu-N1-ITC chelate), 0.2mg

DELFIA® Europium labeling kit for labeling your own biomolecules for use in DELFIA time-resolved fluorescence assays. The ITC chelate reacts with free amine groups in the target biomolecule.
List Price : 496.00 EUR
Alpha Bungarotoxin

Endothelin-1 (human, porcine), [125I]Tyr13

Endothelin-1 (ET-1), labeled with 125I on the tyrosine 13 residue. Endoethlin-1 is a vasoconstrictor that acts as an endogenous agonist at endothelin receptors. Endothelin receptors are a class of GPCRs that are potential drug targets for hypertension and cancer.
Price Range : 1236.00 EUR - 3400.00 EUR
Adenosine 5 Triphosphate 250 µCi

3-Indolylacetic acid, [5-3H(N)]-

3-Indolyacetic acid tritiated at the 5 position. Indole-3-acetic acid (IAA, 3-IAA) is the most common, naturally occurring, plant hormone of the auxin class.
List Price : 2264.00 EUR
PerkinElmer

Membrane Target Systems: Chemoattractant C5a (human varient) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human chemoattractant C5a (human varient) receptor, 400 units.
List Price : 864.00 EUR
Adenosine 5 Triphosphate 250 µCi

Enkephalin, [Tyrosyl-2,6-3H(N)]- (2-D-Penicillamine, 5-D-Penicillamine) (DPDPE)

2-D-Penicillamine, 5-D-Penicillamine (DPDPE), tritiated on the tyrosyl group. Cyclic peptide, sequence: Tyr-D-Pen-Gly-Phe-D-Pen-OH. DPDPE is a synthetic enkephalin opioid peptide that acts as an agonist at delta opiate receptors (δ-opioid receptor, DOR). This product has a scheduled lot release for the second Monday in February and August.
Price Range : 1503.00 EUR - 7300.00 EUR
Alpha Bungarotoxin

RTI-55, [125I]

RTI-55, labeled with 125I. RTI-55 is a nonselective dopamine reuptake inhibitor that is used to assess neuron degradation in Parkinson's disease and other neurodegenerative diseases.
Price Range : 1224.00 EUR - 2439.00 EUR
PerkinElmer

Membrane Target Systems: Nicotinic HM74a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 864.00 EUR
Diclofenac sodium- Phenylacetic acid C14

Iodoantipyrine, 4-[N-Methyl-14C]

4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine has been used to measure cerebral blood flow.
Price Range : 1091.00 EUR - 8900.00 EUR
Adenosine 5 Triphosphate 250 µCi

Dihydroxyphenylethylamine (Dopamine), 3,4-[Ring-2,5,6-3H]

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the ring-2,5,6- position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors.
Price Range : 991.00 EUR - 2403.00 EUR
PerkinElmer

Membrane Target Systems: Serotonin 5HT2c (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human serotonin 5HT2c receptor, 400 units.
List Price : 864.00 EUR
Receptor-expressing cell lines

ValiScreen Adrenergic beta 3 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Alpha Bungarotoxin

Fractalkine (human, recombinant), 125I

Fractalkine (CX3CL1), labeled with 125I. Fractalkine binds to chemokine receptor CX3CR1, and is involved in the adhesion and migration of leukocytes.
Price Range : 1300.00 EUR - 2868.00 EUR
PerkinElmer

WGA PVT SPA 2G

WGA-coated SPA beads, for capturing cell membranes in proximity-based radiometric scintillation assays.
List Price : 3185.00 EUR
Alpha Bungarotoxin

S365057, [Tyr 125I]

NEX396 S36057 is radioiodinated with no carrier added 125I using a lactoperoxidase procedure and is purified by reversed phase HPLC.
Price Range : 1777.00 EUR - 3812.00 EUR
PerkinElmer

ProfilerPro Kinase Peptide Substrate 33, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 33 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 621.00 EUR
PerkinElmer

Membrane Target Systems: Calcitonin CGRP1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 864.00 EUR
PerkinElmer

Membrane Target Systems: Relaxin RXFP3 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 864.00 EUR
PerkinElmer

Membrane Target Systems: Bombesin BB1 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with Bombesin BB1 (human) receptor, in CHO-K1 cells.
List Price : 864.00 EUR
Adenosine 5 Triphosphate 250 µCi

Norepinephrine, Levo-[7-3H]

Levo-Norepinephrine, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET). This product has a scheduled lot release for the third Monday in July.
Price Range : 1850.00 EUR - 15400.00 EUR
PerkinElmer

Membrane Target Systems: Adrenergic alpha 1A (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 864.00 EUR
Alpha Bungarotoxin

Triiodothyronine, ([125I]-T3), Specific Activity: 1080-1320 µCi/µg

Triiodothyronine (T3) labeled with 125I. Triiodothyronine is a thyroid hormone that affects growth and development, body temperature, and heart rate. T3 detection by radioimmunoassay is a common test of thyroid gland function. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 1066.00 EUR - 3078.00 EUR
Adenosine 5 Triphosphate 250 µCi

SCH 23390, [N-Methyl-3H]

SCH-23390 (halobenzazepine), tritiated on the N-methyl group. SCH-23390 acts as an antagonist at the dopamine D1 receptor.
Price Range : 806.00 EUR - 4404.00 EUR
Adenosine 5 Triphosphate 250 µCi

Kainic acid, [Isopropenyl-3H]

Kainic acid, tritiated on the isoproprenyl group. Kainic acid acts as an agonist at kainate glutamate receptors.
Price Range : 3077.00 EUR - 8100.00 EUR
Adenosine 5 Triphosphate 250 µCi

Ethylcarboxamidoadenosine, 5'-N-[Adenine-2,8-3H]-, 250µCi (9.25MBq)

5'-N-Ethylcarboxamidoadenosine (NECA), tritiated at the adenine-2,8 position. 5'-N-Ethylcarboxamidoadenosine is an adenosine analog that acts as an agonist at adenosine receptors A1, A2A, and A3.
List Price : 2447.00 EUR
Adenosine 5 Triphosphate 250 µCi

Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), DL-α-[5-Methyl-3H]

DL-α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), tritiated at the 5-methyl position. AMPA acts as an agonist at the AMPA receptor.
Price Range : 877.00 EUR - 6500.00 EUR

Somatostatin-14 (human, recombinant), [125I], Receptor Grade

NEX446 Tyr11 Somatostatin-14 is radioiodinated with no-carrier-added 125I using amodified lactoperoxidase procedure and is purified by reversed phase HPLC. This method predominantly labels tyrosine residues.
Price Range : 1280.00 EUR - 3386.00 EUR

UniFilter-96 GF/C PEI Coated Plates

PEI-coated GF/C glassfibre filter-bottom 96-well microplate, for receptor binding and cell harvesting assays using a vacuum manifold.
List Price : 1011.00 EUR
PerkinElmer

Membrane Target Systems: Cholecystokinin CCK2 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with Cholecystokinin CCK2 (human) receptor, in HEK-293 cells.
List Price : 864.00 EUR
Alpha Bungarotoxin

Insulin-like Growth Factor-I (human, recombinant), 125I

Insulin-like growth factor 1 (IGF-1), labeled with 125I. IGF-1 acts as an agonist at the IGF-1 receptor, a receptor tyrosine kinase, that plays a role in growth, cancer, and aging. IGF-1 also binds the insulin receptor (IR), another receptor tyrosine kinase involved in glucose homeostasis, diabetes, and cancer.
Price Range : 914.00 EUR - 2243.00 EUR
Adenosine 5 Triphosphate 250 µCi

Naloxone, [N-allyl-2,3,-3H]-

Naloxone radioligand tritiated at the 2,3 position. Naloxone acts as a non-selective, competitive opioid receptor antagonist.
List Price : 2768.00 EUR
PerkinElmer

Membrane Target Systems: Bombesin BB2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 864.00 EUR
Adenosine 5 Triphosphate 250 µCi

(+/-) Epibatidine, [5,6-Bicycloheptyl-3H]

(+/-)-Epibatidine radioligand tritiated at the 5,6-biocycloheptyl position. Epibatidine has analgesic activities, has been shown to function as an agonist at nicotinic acetylcholine receptors, and has been shown to bind muscarinic and serotonin 5-HT3 receptors.
Price Range : 2665.00 EUR - 6400.00 EUR
Adenosine 5 Triphosphate 250 µCi

GR125743, [N-methyl-3H]

GR125743, tritiated on the N-methyl group. GR125743 acts as an antagonist at serotonin 5-HT1B and 5-HT1D receptors.
List Price : 3057.00 EUR
Receptor-expressing cell lines

ValiScreen Muscarinic M4 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Prostanoid DP (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 864.00 EUR
PerkinElmer

Membrane Target Systems: GABA B1b in HEK (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human GABA B1b receptor, 400 units.
List Price : 864.00 EUR
PerkinElmer

Glutathione PVT 750MG ADS

Glutathione-coated SPA beads, for capturing GST-tagged proteins in proximity-based radiometric scintillation assays.
List Price : 798.00 EUR
Adenosine 5 Triphosphate 250 µCi

Oxotremorine-M Acetate, [Methyl-3H]-,>97%, 250µCi (9.25MBq)

Oxotremorine-M acetate, tritiated on the methyl group. Oxotremorine-M acts as a selective agonist at muscarinic acetylcholine receptors.
List Price : 3542.00 EUR
Adenosine 5 Triphosphate 250 µCi

Ketanserin Hydrochloride (R41 468), [Ethylene-3H]

Ketanserin hydrochloride (Sufrexal; R41468), tritiated on the ethylene group. Ketanserin is a high-affinity non-selective antagonist of 5-HT2 receptors.
Price Range : 951.00 EUR - 3159.00 EUR

"Receptor Ligand Binding" 1-50 of 545 Products & Services

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