PerkinElmer

Ligands

OF

Eliminate the need for antibodies and reduce assay time with direct detection using our radiolabeled ligands, which provide for sensitive and quantitative measurement of binding.

  • High specific activity — The majority of our 125I-labeled ligands are offered at maximum specific activity. This means virtually every molecule of ligand provided in the stock vial is radiolabeled. For tritiated ligands (3H ligands), pick a ligand with specific activity above 20 Ci/mmol – all of our tritiated ligands meets or exceeds these requirements.
  • High purity — We offer highly-pure radioligands for the highest specific signal with low background in binding assays.
  • High selectivity — Our broad portfolio of agonists and antagonists offers many options for choosing the most selective compound for your receptor.
  • Validated for receptor binding — all of our radioligand products are tested for receptor binding during development. Additionally, many of our radioligands are used to QC our GPCR and receptor cell lines and cell membrane products.

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  • 1.0 - 10 µCi/mL (3)
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Radionuclide
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Radioisotope
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"Ligands" 1-50 of 121 Products and Services

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Pirenzepine, [N-Methyl-3H]

Pirenzepine, tritiated on the N-methyl group. Pirenzepine acts as a selective antagonist of the muscarinic M1 acetylcholine receptor.
Price Range : 2730.00 EUR - 6900.00 EUR

Muscimol, 3-Hydroxy-5-Aminomethylisoxazole, [Methylene-3H(N)]

3H Muscimol radioligand. Muscimol acts as a potent selective agonist at GABAA receptors. It also acts as a partial agonist at GABAA-rho receptors. This product has a scheduled lot release for the second Monday in February and August. NOTE: NET574001MC will be obsolete soon.
List Price : 2465.00 EUR

Norepinephrine, Levo-[7-3H]

Levo-Norepinephrine, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET). This product has a scheduled lot release for the third Monday in July.
Price Range : 1682.00 EUR - 12800.00 EUR

Butyl Bicyclophosphorothionate, Tertiary-[35S]

Tertiary-Butylbicyclophosphorothionate (TBPS), radiolabeled with S-35. TBPS is a GABAA receptor antagonist.
Price Range : 2819.00 EUR - 4978.00 EUR

Deltorphin II (2-D-Ala), [Tyrosyl-3,5-3H]

Deltorphin II, tritiated at the tyrosyl-3,5 position. Deltorphin II is a selective δ opioid receptor (DOPR) agonist.
Price Range : 1284.00 EUR - 5400.00 EUR

SR141716A, [3H]

Tritiated SR141716A (rimonabant; Acomplia; Zimulti). SR141716A acts as an inverse agonist at the cannabinoid CB1 receptor.
List Price : 3492.00 EUR

Methylhistamine Dihydrochloride, N-α-[methyl-3H]-, 250µCi (9.25MBq)

(R)-α-methylhistamine dihydrochloride, tritiated on the methyl group. α-Methylhistamine is a histamine agonist selective for the histamine H3 receptor.
List Price : 1539.00 EUR

Diltiazem, cis-(+)-[N-Methyl-3H]

cis-(+)-Diltiazem, tritiated at the N-methyl position. Diltiazem is a non-DHP calcium channel blocker.
Price Range : 2304.00 EUR - 5200.00 EUR

Dihydroalprenolol Hydrochloride, Levo-[Ring, Propyl-3H(N)]

Dihydroalprenolol hydrochloride, tritiated on the ring propyl group. Dihydroalprenolol (DHA) is an alprenolol derivative that binds to beta-adrenergic receptors and acts as a beta-adrenergic blocker.
Price Range : 1378.00 EUR - 3133.00 EUR

GR 65630, [N-Methyl-3H]

GR 65630, tritiated on the N-methyl group. GR 65630 acts as a selective antagonist at the 5-HT3 receptor.
Price Range : 903.00 EUR - 4389.00 EUR

Clonidine Hydrochloride, [Benzene Ring-3H]-, 250µCi (9.25MBq)

Clonidine hydrochloride, tritiated on the benzene ring. Clonidine is a drug used to treat high blood pressure, ADHD, anxiety disorders, and drug withdrawal and acts as an agonist at α2 adrenergic and imidazoline receptors.
List Price : 1838.00 EUR

Raclopride, [Methoxy-3H]

Raclopride, [Methoxy-3H]- will have fresh lot dates on the second Monday in March and September.
Price Range : 785.00 EUR - 6300.00 EUR

Hydroxytryptamine Binoxalate (Serotonin Binoxalate), 5-[1-14C]

5-Hydroxytryptamine Binoxalate (Serotonin Binoxalate), labeled with C-14 at the 1-position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors. NEC855 replaces product NEC225, which was labeled at the 2-position.
Price Range : 1073.00 EUR - 4596.00 EUR

CP 55940, [Side Chain-2,3,4-3H(N)]

CP 55,940, tritiated on the side chain-2,3-4 position. CP 55,940 is a synthetic cannabinoid that acts as a full agonist at both cannabinoid CB1 and CB2 receptors, and can also upregulate serotonin 5-HT2A receptors.
Price Range : 941.00 EUR - 6900.00 EUR

DAMGO, [Tyrosyl-3,5-3H(N)]

DAMGO, tritiated at the tyrosyl 3,5 poisition. DAMGO is a synthetic opioid analog with high specificity for the μ-opioid receptor.
Price Range : 2420.00 EUR - 6300.00 EUR

Ketanserin Hydrochloride (R41 468), [Ethylene-3H]

Ketanserin hydrochloride (Sufrexal; R41468), tritiated on the ethylene group. Ketanserin is a high-affinity non-selective antagonist of 5-HT2 receptors.
Price Range : 865.00 EUR - 7700.00 EUR

MESULERGINE, [N-METHYL-3H]-, 250 µCi

Mesulergine, tritiated on the N-methyl group. Mesulergine acts as an antagonist at serotonin 5-HT2A and 5-HT2C receptors, and as a partial agonist at dopamine receptors.
List Price : 2500.00 EUR

NAAG, [Glutamate-3,4-3H]

NAAG radioligand tritiated at the 3,4 position. NAAG is a peptide neurotransmitter that activates the metabotropic glutamate receptor type 3.
Price Range : 1821.00 EUR - 3971.00 EUR

Rosiglitazone, DL- [3H]-

Tritiated DL-Rosiglitazone (Avandia). Rosiglitazone acts as a selective agonist at peroxisome proliferator-activated receptors (PPARs).
List Price : 1977.00 EUR

Ro 15-1788, [N-Methyl-3H]

Ro 15-1788 (flumazenil), tritiated on the N-methyl group. Ro 15-1788 acts as a selective benzodiazepine antagonist.
Price Range : 913.00 EUR - 6800.00 EUR

TCP, [Piperdyl-3,4-3H(N)]

Tenocyclidine (TCP), tritiated at the piperdyl-3,4 position. TCP acts as an antagonist at N-methyl-D-aspartate receptor (NMDA receptors).
Price Range : 911.00 EUR - 3321.00 EUR

GBR 12935, [Propylene-2,3-3H]

GBR 12935, tritiated at the propylene-2,3 position. GBR 12935 is a piperazine derivative that acts as a selective dopamine reuptake inhbitor.
Price Range : 3002.00 EUR - 8500.00 EUR

Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), DL-α-[5-Methyl-3H]

DL-α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), tritiated at the 5-methyl position. AMPA acts as an agonist at the AMPA receptor.
Price Range : 797.00 EUR - 5900.00 EUR

WIN 35428, [N-Methyl-3H]

WIN 35428 [(–)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane], tritiated on the N-methyl group. WIN 35428 acts as an antagonist at dopamine transporters (DATs).
Price Range : 992.00 EUR - 7100.00 EUR

Verapamil Hydrochloride, [N-Methyl-3H]

Verapamil hydrochloride, tritiated on the N-methyl group. Verapamil acts as a calcium channel blocker (CCB).
Price Range : 957.00 EUR - 3619.00 EUR

Sphingosine-1-phosphate, 33P

As of August 17, 2018, we will be discontinuing all P33 ligands, P33 nucleotides and P33 nuclides. The last day for shipping any of these products will be August 16, 2018. Sphingosine-1-phosphate is a bioactive lipid and can be used as an endogenous ligand in sphingosine-1-phosphate (S1P) receptor binding assays.
Price Range : 18300.00 EUR - 45200.00 EUR

SCH 23390, [N-Methyl-3H]

SCH-23390 (halobenzazepine), tritiated on the N-methyl group. SCH-23390 acts as an antagonist at the dopamine D1 receptor.
Price Range : 732.00 EUR - 4003.00 EUR

Diprenorphine [15,16-3H]

Diprenorphine (Revivon; M5050; diprenorfin), tritiated at the 15,16- position. Diprenorphine acts as a non-selective antagonist at opioid receptors.
Price Range : 838.00 EUR - 1743.00 EUR

WAY100635, [METHOXY-3H], 250 uCi

WAY-100635, tritiated on the methoxy group. WAY-100635 acts as an antagonist at serotonin 5-HT1A receptors. It also acts as an agonist at dopamine D4 receptors.
List Price : 5100.00 EUR

Enkephalin (2-D-Alanine-5-D-Leucine), [Tyrosyl-3,5-3H(N)]-, 250µCi (9.25MBq)

DADLE, tritiated on the tyrosyl group. Peptide sequence: Tyr-D-Ala-Gly-L-Phe-D-Leu. DADLE is a synthetic enkephalin analog considered selective for the delta opioid receptor, but has been shown to bind the mu opioid receptor as well.
List Price : 2368.00 EUR

Retinoic Acid, [11,12-3H]9-cis-

9-cis-retinoic acid tritiated at the 11,12 position. It is a form of vitamin A and activates retinoic acid receptors (RARs).
List Price : 3653.00 EUR

Norepinephrine, Levo-[ring-2,5,6-3H]

Levo-Norepinephrine, tritiated on the ring group. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).
Price Range : 1865.00 EUR - 11900.00 EUR

Citalopram, [N-Methyl-3H]

Citalopram, tritiated at the N-methyl group. Citalopram is a selective serotonin reuptake inhibitor (SSRI) antidpressant drug, and has been shown to block the serotonin transporter (SERT, 5-HTT).
Price Range : 1559.00 EUR - 3403.00 EUR

(+)-Pentazocine, [Ring-1,3-3H]

(+)-Pentazocine radioligand tritiated at the 1,3 position on the ring. Pentazocine is a synthetic opioid shown to bind sigma 1 receptor.
Price Range : 874.00 EUR - 6800.00 EUR

Chloramphenicol, [Ring-3,5-3H]

Chloramphenicol, tritiated at the ring-3,5 position. Chloramphenicol is a broad spectrum antibiotic that binds to a receptor site on the 50S subunit of the bacterial ribosome, inhibiting peptidyl transferase.
Price Range : 2652.00 EUR - 5800.00 EUR

Imipramine Hydrochloride, [Benzene ring-3H(N)]-, 250µCi (9.25MBq)

Imipramine hydrochloride, tritiated on the benzene ring. Imipramine is believed to act as an antagonist at certain serotonin, histamine, and cholinergic receptors.
List Price : 2072.00 EUR

MK-912, [3H(G)]

MK-912 radioligand. MK-912 acts as a selective antagonist at the α2-adrenoceptor. This product has a scheduled lot release for the second Monday in October. NOTE: NET1227025UC will be obsoleted soon.
List Price : 4060.00 EUR

Serine, D-[3H(G)]-, 250µCi (9.25MBq)

Tritiated D-Serine. D-Serine acts as an agonist at N-methyl-D-aspartate receptors (NMDA receptors).
List Price : 2788.00 EUR

DTG (1,3-Di-o-tolylguanidine, [p-ring-3H]-), [5-3H(N)]

DTG (Ditolylguanidine), tritiated on the p-ring and at the 5- position. DTG is a selective sigma receptor (σ-receptor) agonist.
Price Range : 3055.00 EUR - 7800.00 EUR

3-INDOLYLACETIC ACID, [5-3H(N)]-

3-Indolyacetic acid tritiated at the 5 position. Indole-3-acetic acid (IAA, 3-IAA) is the most common, naturally occurring, plant hormone of the auxin class.
List Price : 2059.00 EUR

Nociceptin, [Leucyl-3,4,5-3H], 50µCi (1.85MBq)

Nociceptin, tritiated on the leucine residue. Nociceptin is the endogenous ligand for the nociceptin receptor (NOP, ORL-1).
List Price : 4542.00 EUR

Flunitrazepam, [Methyl-3H]

Flunitrazepam (Rohypnol), tritiated on the methyl group. Flunitrazepam is a benzodiazepine and acts as an agonist at GABAA (γ-aminobutyric acid) receptors.
Price Range : 744.00 EUR - 7500.00 EUR

CGP 39653, [Propyl-2,3,3H]

CGP 39653, tritiated at the propyl-2,3 position. CGP 39653 acts as an N-methyl-D-aspartate (NMDA) antagonist.
Price Range : 898.00 EUR - 7700.00 EUR

COUMARIN, 7-ETHOXY, [3- 14C]-

50 µCi quantities of 7-ETHOXY-[3-14C]-Coumarin are available for your research.
List Price : 2734.00 EUR

Neurotensin, [3,11-Tyrosyl-3,5-3H(N)]

Neurotensin radioligand tritiated at the 3,5 position of the tyrosine residues. Neurotensin is a neuropeptide that acts as an agonist on the neurotensin receptor family.
Price Range : 935.00 EUR - 4911.00 EUR

Colchicine, [ring C, Methoxy-3H]-, 250µCi (9.25MBq)

Colchicine, tritiated at the ring C methoxy- position. Colchicine binds tubulin to prevent microtubule polymerization, and is used to treat gout.
List Price : 2471.00 EUR

Iodoantipyrine, 4-[N-Methyl-14C]

4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine has been used to measure cerebral blood flow.
Price Range : 992.00 EUR - 8100.00 EUR

Astemizole, [O-Methyl-3H]

Astemizole (Hismanal) tritiated at the O-methyl group. Atemizole is an antagonist of the histamine H1-receptor and has been shown to block hERG potassium channels.
Price Range : 986.00 EUR - 9800.00 EUR

Prazosin, [7-Methoxy-3H]

Prazosin, tritiated at the 7-methoxy position. Prazosin acts as an inverse agonist at the α1-adrenergic receptor.
Price Range : 982.00 EUR - 7800.00 EUR

Cytisine HCl, [3,5-3H(N)]

Cytisine HCl, [3,5-3H(N)]- will have fresh lot dates on the second Monday in April.
Price Range : 838.00 EUR - 3011.00 EUR

"Ligands" 1-50 of 121 Products and Services

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