PerkinElmer

GPCR

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Accelerate your research into G-protein-coupled receptors with integrated solutions for any GPCR target, including Gs-, Gq- and Gi-coupled receptors. Count on us to help you identify and monitor

  • Effects of GPCR pathway activation: intracellular calcium, cAMP, phospho-ERK, inositol phosphate
  • Reporter gene expression
  • Receptor ligand binding
  • GTP binding

Our state-of-the-art GPCR solutions portfolio is extensive and includes:

  • Scalable GPCR cellular imaging, detection instrumentation and liquid handling systems for radiometric fluorescence, luminescence or photometric detection
  • Optimized cell-based assay platforms
  • Versatile reagents—GPCR cell lines; frozen, ready-to-use cells; radioligands; ligands; cloned receptor membranes

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Product Type
  • Accessories (6)
  • Instruments (6)
  • Reagents (108)
Application
  • cAMP (8)
  • Drug Discovery & Development (49)
  • Kinase (6)
  • Multiplexing (8)
  • Protein Analysis & Detection (12)
Assay Points
  • 100 (8)
  • 1000 (1)
  • 10000 (14)
  • 500 (13)
  • 50000 (14)
Assay Target
  • Akt1 (2)
  • Akt1/2 (1)
  • Akt1/2/3 (6)
  • cAMP (3)
  • CREB (2)
  • ERK1/2 (15)
Assay Target Class
  • GPCR (46)
  • Phosphoprotein (21)
  • Protein (6)
Assay Validated
  • Binding (35)
  • Calcium Fluorescence (4)
  • Calcium Luminescence (20)
  • cAMP (5)
  • Downstream Phosphorylation (4)
Automation Compatible
  • Yes (31)
Concentration
  • 1.0 - 10 mCi/mL (2)
  • 1.12 mCi/mL (2)
  • 171.9 µCi/mL (2)
  • 50 µCi/mL (1)
  • 83.8 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • <1.0 µCi/mL (1)
Detection Method
  • Absorbance (5)
  • Alpha (29)
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  • Image-based Cytometry (1)
  • Label-free (2)
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  • Radiometric (23)
  • Time-Resolved Fluorescence (TRF) (7)
  • TR-FRET (2)
Experimental type
  • In vitro (24)
Format
  • Microplates (27)
Host Cell
  • 1321N1 (2)
  • A9 (1)
  • CHO-K1 (27)
  • HEK293 (23)
  • HT29 (1)
  • L Cells (1)
  • U373 (1)
  • UC11 (1)
Label Position
  • Generally Labeled (1)
  • Nominally Labeled (16)
  • Specifically Labeled (6)
Maximum Temperature (Celsius)
  • 40-50 (2)
  • 50-60 (2)
Molecular modification
  • Phosphorylation (14)
Product Brand Name
  • AequoScreen (6)
  • AequoZen (14)
  • Alpha SureFire Ultra Multiplex (8)
  • AlphaLISA SureFire Ultra (3)
  • AlphaPlex (8)
  • AlphaScreen (1)
  • AlphaScreen SureFire (14)
  • cAMPZen (5)
  • EnSight (1)
  • EnSpire (3)
  • EnVision (3)
  • LANCE (1)
  • LANCE Ultra (1)
  • Membrane Target Systems (32)
  • NEN Radiochemicals (7)
  • NEN Radiolabeled Ligands (16)
  • Victor (3)
  • ViewLux (1)
Radionuclide
  • 125I (16)
  • 3H (7)
Radioisotope
  • H-3 (7)
  • I-125 (16)
Receptor Type
  • 5-Hydroxytryptamine (1)
  • 5-Hydroxytryptamine (Serotonin) (4)
  • Adenosine (13)
  • Adrenergic (5)
  • Anaphylatoxin (1)
  • Calcitonin (2)
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  • Peptide P518 (2)
  • Prostanoid (1)
  • Tachykinin (1)
  • Urotensin (1)
  • Vasoactive Intestinal Peptide (1)
  • Vasopressin (4)
Target Species
  • Human (11)
Therapeutic Area
  • Angiogenesis (1)
  • Cardiovascular (28)
  • Central Nervous System (33)
  • Diabetes (9)
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  • Inflammation (32)
  • Metabolic (16)
  • Obesity (5)
  • Pain (15)
  • Renal (2)
Volume
  • 0-50 (43)
  • 51-100 (1)
  • 201-250 (3)
  • 351-400 (19)
  • 451-500 (6)
  • Over 500 (6)

"GPCR" 1-50 of 120 Products and Services

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EnSight multimode plate-reader

EnSight Multimode Plate Reader

The EnSight multimode plate reader combines labeled, label-free & image-based cytometry technologies in a single benchtop platform. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.
EnVision_Alone_Left_Angle

EnVision Multilabel Plate Reader

The EnVision Multilabel Plate Reader provides the highest speed, ultra-high throughput, and maximum sensitivity across  all detection technologies, so that your high throughput screening applications won’t be held back by unreliable results or equipment that can’t keep up to the demands of escalating workloads and new assays.

EnSpire Alpha Plate Reader

The EnSpire Alpha Plate Reader provides proven Alpha technology to your lab at an affordable price and from the Alpha detection leader.

EnSpire Multimode Plate Reader

EnSpire® Multimode Plate Reader is designed to meet the demands of multi-user research environments, providing high performance technology and flexibility for a range of applications without compromising sensitivity. Combine this with our expertise and portfolio of reagents, PerkinElmer offers an unrivaled solution to your application needs.

ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.
VictorX_ImageA_320px

VICTOR Multilabel Plate Reader

The next generation VICTOR X Multilabel Plate Reader platform delivers flexibility, speed and performance to research labs of all sizes.
List Price : 1353.00 EUR
List Price : 682.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-ERK1/2 (Thr202/Tyr204) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-ERK 1/2 (Thr202/Tyr204) assay is a sandwich immunoassay for quantitative detection of phospho-ERK 1/2 (phosphorylated on Thr202/Tyr204 in ERK1, or Thr185/Tyr187 in ERK2) in cellular lysates using Alpha Technology.
Price Range : 493.00 EUR - 28600.00 EUR
PerkinElmer

Membrane Target Systems: Neurotensin NTS1(Leu194) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human neurotensin NTS1 (Leu194) receptor, 400 units.
List Price : 762.00 EUR
PerkinElmer

Membrane Target Systems: Chemoattractant C5a (human varient) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human chemoattractant C5a (human varient) receptor, 400 units.
List Price : 784.00 EUR
PerkinElmer

Membrane Target Systems: Adenosine A3 (rat) membrane preparation

Cell membranes prepared from cells stably-transfected with rat Adenosine A3 receptor, in HEK-293 cells.
List Price : 784.00 EUR
SureFire principle

AlphaScreen SureFire Monoclonal ERK p-T202/Y204 HV, 100 Assay Points

The AlphaScreen® SureFire® Monoclonal p-ERK1/2 (Thr202/Tyr204) assay is a sandwich immunoassay for quantitative detection of phospho-ERK1/2 (phosphorylated on Thr202/Tyr204) in cellular lysates using Alpha Technology. This assay performs similarly to the TGRES SureFire kit, but contains a monoclonal antibody for phospho-ERK detection.
List Price : 451.00 EUR
SureFire principle

AlphaScreen SureFire Akt 123 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt1/2/3 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
Price Range : 451.00 EUR - 17800.00 EUR

N-succinimidyl-3-(4-hydroxy-3-[125I]iodophenyl)propionate, Bolton-Hunter Reagent, 1 mCi

Anhydrous benzene A charcoal trap is provided with each vial. Bolton-Hunter reagent. Radiochemical Purity is>95%.
List Price : 1179.00 EUR
PerkinElmer

Membrane Target Systems: Thromboxane TP (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Thromboxane TP receptor, in HEK-293 cells.
List Price : 784.00 EUR
Alpha SureFire Ultra Multiplex kits

Alpha SureFire Ultra Multiplex p-AKT (Ser473) (directly coupled) Kit

Single target-only kit for multiplexing to other AlphaLISA SureFire Ultra assay kits. The Alpha SureFire® Ultra Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
Price Range : 418.00 EUR - 24300.00 EUR
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, HEK293 (+Gα16)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 735.00 EUR
alphascreen surefire total

AlphaScreen SureFire Monoclonal Total ERK, 50,000 Assay Points

The AlphaScreen® SureFire® total ERK assay is a sandwich immunoassay for quantitative detection of ERK (both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization for phosphorylation studies. This assay performs similarly to the TGRTES SureFire kit, but contains a monoclonal antibody for ERK detection.
List Price : 17800.00 EUR
SureFire principle

AlphaScreen SureFire Akt 1/2 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt 1/2 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt 1/2 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
Price Range : 1504.00 EUR - 16200.00 EUR
PerkinElmer

Membrane Target Systems: Galanin Gal1 (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human galanin Gal1 receptor, 400 units.
List Price : 762.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-AKT1/2/3 (Thr308) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-AKT1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-AKT1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
Price Range : 493.00 EUR - 28600.00 EUR

LANCE cAMP Detection Kit

LANCE® TR-FRET cAMP assay kit, for Gs- and Gi-coupled GPCR functional assays.
Price Range : 143.00 EUR - 6400.00 EUR
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ Multiplex p-ERK (Eu) (directly coupled) HV Kit, 100 Assay Points

Single target-only kit for multiplexing to other AlphaLISA SureFire Ultra assay kits. The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
List Price : 418.00 EUR
Alpha SureFire Ultra Multiplex kits

Alpha SureFire Ultra Multiplex p-AKT(Ser473) (Eu) + p-ERK (Tb) Kit

The Alpha SureFire® Ultra Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
Price Range : 752.00 EUR - 43700.00 EUR
Receptor-expressing cell lines

AequoZen FroZen cells, Adrenergic α2A, Human Recombinant, CHO-K1

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 735.00 EUR
Receptor-expressing cell lines

Adenosine A2A AequoScreen; cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.

QRFP-43, [125I], Human Radioligand, 25µCi (925kBq)

QRFP-43 is a 43 amino acid polypeptide starting from N-terminal pyroglutamic acid and ending at C-terminal arginine-phenylalanine-amide. The intravenous administration of QRFP-43 caused the release of aldosterone, suggesting that QRFP and its receptor have a regulatory function in the rat adrenal gland.
List Price : 3050.00 EUR
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, CHO-K1 (+Gα16)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 735.00 EUR
PerkinElmer

Membrane Target Systems: Serotonin 5HT1a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from cells stably-transfected with human serotonin 5HT1a receptor
List Price : 784.00 EUR
PerkinElmer

Membrane Target Systems: GABA B1b in HEK (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human GABA B1b receptor, 400 units.
List Price : 784.00 EUR
PerkinElmer

Membrane Target Systems: Histamine H2 (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human Histamine H2 receptor, 400 units.
List Price : 784.00 EUR
Receptor-expressing cell lines

cAMPZen Frozen cells, Adenosine A2B, Human Recombinant, HEK293

Our frozen, irradiated cAMPZen cells express a variety of GPCRs for binding and functional assays. No cell culture is required prior to testing.
List Price : 460.00 EUR

CGRP (human), [125I]-, 50µCi

NEX354 Human CGRP binds to human CGRP receptors in the central nervous system and peripheral nervous system. [125I]-CGRP (human) will be useful in the characterization of CGRP receptors.
List Price : 2265.00 EUR
PerkinElmer

AlphaScreen cAMP Detection Kit

AlphaScreen no-wash assay kit for quantitative detection of cAMP.
Price Range : 406.00 EUR - 13900.00 EUR
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 (Eu) + Total ERK 545 (Tb) Kit

The Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 + Total ERK assay kit is used to measure both the phosphorylation (Thr202/Tyr204) and total levels of endogenous “extracellular signal-regulated kinase 1 and 2” (ERK 1/2) in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure ERK 1/2 activation by either recombinant or endogenous receptors, and can be applied to primary cells.
Price Range : 752.00 EUR - 43700.00 EUR
SureFire principle

AlphaScreen SureFire Monoclonal ERK p-T202/Y204, 500 Assay Points

The AlphaScreen® SureFire® Monoclonal p-ERK1/2 (Thr202/Tyr204) assay is a sandwich immunoassay for quantitative detection of phospho-ERK1/2 (phosphorylated on Thr202/Tyr204) in cellular lysates using Alpha Technology. This assay performs similarly to the TGRES SureFire kit, but contains a monoclonal antibody for phospho-ERK detection.
List Price : 1650.00 EUR
PerkinElmer

Membrane Target Systems: Vasopressin V2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human Vasopressin V2 receptor, 400 units.
List Price : 784.00 EUR
PerkinElmer

Membrane Target Systems: Serotonin 5HT6 (rat) membrane preparation

Cell membranes prepared from cells stably-transfected with rat Serotonin 5-HT6 receptor, in HEK-293 cells.
List Price : 784.00 EUR

LANCE Ultra cAMP Detection Kit

The LANCE® Ultra cAMP assay is a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay designed to measure cAMP produced upon modulation of adenylyl cyclase activity by G-protein coupled receptors (GPCRs).
Price Range : 544.00 EUR - 7100.00 EUR
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ HV Multiplex p-Akt 1/2/3 (S473) (Eu) + Total Akt1 (Tb) Kit

The Alpha SureFire® Ultra™ HV Multiplex p-Akt 1/2/3 (Ser473) + Total Akt 1 assay kit is used to measure both the phosphorylation (Ser473) and total levels of endogenous Akt in cellular lysates. The kit measures phosphorylation on Ser473 of Akt 1/2/3, and total levels of Akt 1 only. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure Akt (Ser473) activation by either recombinant or endogenous receptors, and can be applied to primary cells.
Price Range : 752.00 EUR - 43700.00 EUR
Receptor-expressing cell lines

Adenosine A3, Human Recombinant, CHO-K1 AequoZen® Frozen cells

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 735.00 EUR
Receptor-expressing cell lines

Adenosine A2B AequoScreen; cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
Receptor-expressing cell lines

cAMPZen Frozen cells, Adrenergic α2A, Human Recombinant, CHO-K1

Our frozen, irradiated cAMPZen cells express a variety of GPCRs for binding and functional assays. No cell culture is required prior to testing.
List Price : 463.00 EUR
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, 1321N1

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 735.00 EUR
SureFire principle

AlphaScreen SureFire p-Akt 1/2/3 (Thr308) research kit

The AlphaScreen® SureFire® p-Akt1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
Price Range : 1650.00 EUR - 17800.00 EUR
Receptor-expressing cell lines

Adenosine A3 AequoScreen® cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
PerkinElmer

Membrane Target Systems: Opioid Kappa (OP2) (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human opioid kappa (OP2) receptor, 400 units.
List Price : 784.00 EUR
PerkinElmer

Membrane Target Systems: Melanocortin MC3 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Melanocortin MC3 receptor, in HEK-293 cells.
List Price : 784.00 EUR
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, CHO-K1 (+Gαq/i5)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 735.00 EUR

"GPCR" 1-50 of 120 Products and Services

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