PerkinElmer

Enzymology

OF

Find the end-point and real-time kinetic reagents and instruments you need for your enzymatic assays. We offer:

  • Radiolabeled substrates for highly-sensitive kinetic assays and antibody-free screening
  • TR-FRET, TRF, and Alpha no-wash technologies for fast and simple measurement of biochemical and cellular enzymatic activity
  • Microfluidic mobility-shift assays (MSA) for radiometric analysis of substrate conversion, kinetics, and mechanism-of-action
  • Multi-mode plate readers for maximal speed and throughput independent of technology platform

  • Products and Services

  • Resources, Events & More

Narrow your results
Product Type
  • Consumables (2)
  • Instruments (1)
  • Reagents (271)
Antibody conjugates
  • Anti-acetyl-lysine (1)
  • Anti-Acetyl-Lysine (1)
  • Anti-H3 (C-term) (1)
  • Anti-H3K27ac (2)
  • Anti-H3K27me2 (1)
  • Anti-H3K27me2-1 (1)
  • Anti-H3K27me3 (2)
  • Anti-H3K36me2 (2)
  • Anti-H3K4 (3)
  • Anti-H3K4me1-2 (2)
  • Anti-H3K9/H3K27 (1)
  • Anti-H3K9/K27 (1)
  • Anti-H3K9ac (2)
  • Anti-H3K9me2 (2)
  • Anti-H3R2me (1)
  • Anti-H4K20me1 (1)
  • Anti-H4R3me (2)
  • Anti-methyl arginine (1)
  • Anti-methyl-Arg (1)
  • Anti-O-GlcNAc (1)
  • Anti-O-linked-GlcNAc (1)
  • Anti-P-PKA (1)
  • Anti-P-Ser (1)
  • Anti-P-Ser 14-3-3 (1)
  • Anti-P-Tyr-100 (1)
  • Anti-p53K382ac (2)
  • Anti-phospho-4EBP1 (1)
  • Anti-phospho-Acetyl-CoA-Carboxylase (1)
  • Anti-phospho-Crosstide (1)
  • Anti-phospho-glycogen synthase (1)
  • Anti-phospho-Histone H3 (2)
  • Anti-phospho-I?Ba (1)
  • Anti-phospho-MEK1/2 (1)
  • Anti-phospho-p70S6K (1)
  • Anti-phospho-PKC (1)
  • Anti-phospho-PLK (1)
  • Anti-phospho-rpS6 (1)
  • Anti-phospho-serine (2)
  • Anti-phospho-threonine (2)
  • Anti-phospho-Topo IIa (1)
  • Anti-phospho-Tyrosine Hydroxylase (1)
  • P-Tyr-100 (1)
  • PT66 (2)
  • PY20 (2)
  • Streptavidin/Phosphosensor (1)
  • Streptavidin/PT66 (1)
  • Streptavidin/PY20 (1)
Application
  • Drug Discovery & Development (3)
  • Epigenetics (47)
  • Kinase (139)
  • Multiplexing (6)
  • Protein Analysis & Detection (96)
Assay Points
  • 100 (29)
  • 1000 (1)
  • 10000 (79)
  • 500 (88)
  • 5000 (10)
  • 50000 (81)
Assay Target
  • 4EBP1 (3)
  • Akt1 (3)
  • Akt1/2 (1)
  • Akt1/2/3 (6)
  • ALK (2)
  • ATF1 (1)
  • ATF2 (1)
  • BAD (2)
  • c-Jun (2)
  • c-Met (1)
  • Caspase-9 (1)
  • Chk-1 (1)
  • Chk-2 (1)
  • Cofilin (1)
  • CREB (2)
  • EGFR (2)
  • eIF2α (1)
  • eIF4E (2)
  • Elk1 (1)
  • ErbB2 (1)
  • ERK1/2 (7)
  • GAPDH (1)
  • GSK3α (1)
  • GSK3β (5)
  • Histone H2A (1)
  • Histone H3 (11)
  • Hsp27 (1)
  • IGFR (1)
  • IKKα (3)
  • INSR (2)
  • IκBα (1)
  • JNK1/2/3 (5)
  • JNK1/3 (1)
  • MEK1 (5)
  • MKK3/6 (1)
  • MKK4 (1)
  • mTOR (5)
  • NFκB (4)
  • p38 MAPK (3)
  • p53 (2)
  • p70 S6K (4)
  • PDK1 (1)
  • S6RP (6)
  • SLP-76 (4)
  • SMAD1 (2)
  • SMAD2 (1)
  • SMAD3 (2)
  • STAT1 (1)
  • STAT3 (6)
  • STAT4 (1)
  • STAT5 (2)
  • Topo IIα (2)
  • VEGF2 Receptor (2)
  • β-Catenin (1)
Assay Target Class
  • Histone (11)
  • Phosphoprotein (107)
  • Protein (6)
Automation Compatible
  • Yes (215)
Detection Method
  • Alpha (152)
  • DELFIA TRF (6)
  • Fluorescence (1)
  • Radiometric (4)
  • Time-Resolved Fluorescence (TRF) (64)
  • TR-FRET (58)
Experimental type
  • In vitro (197)
Fluorophore
  • 5-FAM (31)
  • Eu-N1 (6)
  • Eu-W1024 (39)
  • FITC (3)
  • ULight (19)
Format
  • Microplates (216)
Molecular modification
  • Acetylation (12)
  • GlcNAc (1)
  • Glycosidation (1)
  • Methylation (26)
  • Phosphorylation (119)
  • Total (1)
  • Unmodified (4)
Product Brand Name
  • Alpha SureFire Ultra Multiplex (6)
  • AlphaLISA (32)
  • AlphaLISA SureFire Ultra (53)
  • AlphaPlex (7)
  • AlphaScreen (3)
  • AlphaScreen SureFire (60)
  • DELFIA (6)
  • Labchip EZ Reader (47)
  • LabChip EZ Reader (1)
  • LANCE (7)
  • LANCE Ultra (51)
  • SPA Enzymatic Assays (3)
Radioisotope
  • H-3 (3)
Sample Volume
  • 2 mL (1)
  • 35 mL (1)
  • 400 mL (1)
Target Species
  • Human (108)
Therapeutic Area
  • Epigenetics (11)
Volume
  • 0-50 (70)
  • 51-100 (1)
  • 201-250 (1)
  • 351-400 (1)
  • 451-500 (48)
  • Over 500 (47)

"Enzymology" 1-50 of 274 Products and Services

Sort
Per Page
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.
AlphaLISA Cellular Epigenetics kits

AlphaLISA dimethylated-Histone H3 Lysine 36 (H3K36me2) Cellular Detection Kit

This kit is designed for the detection of di-methylated Histone H3 Lysine 36 (H3K36me2) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 594.00 EUR - 10600.00 EUR
AlphaLISA Cellular Epigenetics kits

AlphaLISA Tri-Methyl-Histone H3 Lysine 27 (H3K27me3) Cellular Detection Kit

This kit is designed for the detection of tri-methylated Histone H3 Lysine 27 (H3K27me3) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 594.00 EUR - 10600.00 EUR
PerkinElmer

Phosphodiesterase [3H] cGMP SPA Enzyme Assay

cGMP radioimmunoassay kit using Scintillation Proximity Assay (SPA) beads
List Price : 2975.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-EGFR (Tyr1068) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-EGFR (Tyr1068) assay is a sandwich immunoassay for quantitative detection of phospho-EGF Receptor (phosphorylated on Tyr1068) in cellular lysates using Alpha Technology.
Price Range : 493.00 EUR - 28600.00 EUR

AlphaLISA Anti-mono-methyl-Histone H4 Lysine 20 Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against Histone H4 that is mono-methylated at lysine 20 (H4K20me1). These beads can be used for AlphaLISA no-wash epigenetic writer and eraser assays.
Price Range : 1213.00 EUR - 22100.00 EUR

LANCE Ultra Europium-anti-phospho-CREB (Ser133)

Monoclonal antibody labeled with the LANCE® Eu-W1024-ITC chelate. This antibody recognizes specifically phosphorylated Ser133 in the cAMP response element binding (CREB) protein. CREB (Ser 133) can be phosphorylated by a variety of kinases including MSK1, PKA and PKC isoforms.
Price Range : 950.00 EUR - 4114.00 EUR
PerkinElmer

LANCE Ultra ULight™-Histone H3 (Thr3/Ser10) Peptide

ULight™-labeled synthetic peptide derived from residues 463-480 of human RAC-alpha serine/threonine-protein kinase (AKT1 or PKB). AKT/PKB can be phosphorylated at Ser473 by the mTOR/Rictor complex and MAPKAP kinase 2. Peptide sequence : CSERRPHFPQFSYSASGTAR
Price Range : 251.00 EUR - 1024.00 EUR
AlphaLISA Cellular Epigenetics kits

AlphaLISA Human Total Histone H2A Cell-based Assay Kit

AlphaLISA no-wash assay kit for the detection of total human Histone 2A (H2A) in cell extracts or cells in culture medium.
Price Range : 744.00 EUR - 13900.00 EUR

Anti-Histone H3 (C-term) AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads designed to capture Histone H3 in a homogeneous AlphaLISA assay for DOT1L. Use in conjunction with biotinylated anti-H3K79me2 (AL148).
Price Range : 1213.00 EUR - 22100.00 EUR
SureFire principle

AlphaScreen SureFire JNK 1-3 (p-Thr183;Tyr185) Assay Kit

The AlphaScreen® SureFire® p-JNK1/3 (Thr183/Tyr185) assay is a sandwich immunoassay for quantitative detection of phospho-JNK1/3 (phosphorylated on Thr183/Tyr185) in cellular lysates using Alpha Technology.
Price Range : 1504.00 EUR - 16200.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-eIF2α (Ser51) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-eIF2α (Ser51) assay is a sandwich immunoassay for quantitative detection of phospho-eIF2α (phosphorylated on Ser51) in cellular lysates using Alpha Technology.
Price Range : 493.00 EUR - 28600.00 EUR

DELFIA Eu-N1 Anti-Phosphotyrosine (PY20)

Europium-labeled anti-phosphotyrosine (PY20) antibody, for use in DELFIA time-resolved fluorescence (TRF) kinase assays, phosphoprotein detection, and phosphoprotein binding assays.
Price Range : 220.00 EUR - 2774.00 EUR

AlphaLISA Biotinylated Anti-Histone H3 (C-ter) Antibody

Biotinylated antibody against the C-terminal end of human histone H3, for use in Alpha no-wash epigenetic assays using full-length histone H3 as substrate.
Price Range : 946.00 EUR - 3348.00 EUR

LANCE Ultra ULight™-IkappaB-alpha (Ser32/36) peptide

ULight™-labeled synthetic peptide containing the amino acid residues surrounding Ser32/36 of human IkappaB-alpha. The ULight-IkappaB-alpha peptide can be phosphorylated at Ser 32/36 by the IKKβ kinase. Peptide core motif: RHDSGLDSM
Price Range : 262.00 EUR - 715.00 EUR

Phosphodiesterase [3H] cAMP SPA Enzyme Assay

cAMP radioimmunoassay kit using Scintillation Proximity Assay (SPA) beads
List Price : 2975.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-Insulin Receptor β (Tyr1150/1151) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-Insulin Receptor β (Tyr1150/1151) assay is a sandwich immunoassay for quantitative detection of phospho-INSR (phosphorylated on Tyr1150/1151) in cellular lysates using Alpha Technology.
Price Range : 493.00 EUR - 28600.00 EUR
AlphaLISA Cellular Epigenetics kits

AlphaLISA dimethylated-Histone H3 Lysine 79 (H3K79me2) Cellular Detection Kit

This kit is designed for the detection of di-methylated Histone H3 Lysine 79 (H3K79me2) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 594.00 EUR - 10600.00 EUR
AlphaLISA Cellular Epigenetics kits

AlphaLISA unmodified Histone H3 Lysine 4 (H3K4) Cellular Detection Kit

This kit is designed to be used as a control for the AlphaLISA Epigenetic Cellular Detection Kits, through detection of unmodified Histone H3 Lysine 4 (H3K4) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 594.00 EUR - 10600.00 EUR
PerkinElmer

LANCE Ultra Europium-anti-phospho-PKC (Ala25Ser) peptide Antibody

Mouse monoclonal antibody labeled with the LANCE® Europium chelate. This antibody detects phospho-Ser in a synthetic peptide (RFARKGSLRQKNV) only after the peptide is phosphorylated by PKC or PKA kinases. The synthetic peptide is derived from amino acids 19-31 of human PKCα in which Ala25 is mutated to Ser. Sequence motif recognized: RFARKG-pS-LRQKNV
Price Range : 1745.00 EUR - 6000.00 EUR
PerkinElmer

Histone 4 Acetylated Peptide, for LabChip EZ Reader

Fluorescently-labelled Histone 4 Peptide (Acetylated) for Epigenetic Assays (Enzyme inhibiton, target discovery, lead optimization)
List Price : 544.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-eIF4E (Ser209) Assay Kits

The AlphaLISA® SureFire® Ultra™ p-eIF4E(Ser209) assay is a sandwich immunoassay for quantitative detection of phospho-eIF4E (phosphorylated on Ser209) in cellular lysates using Alpha Technology.
Price Range : 493.00 EUR - 28600.00 EUR

AlphaLISA Anti-unmodified Histone H3 Lysine 4 (H3K4) Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against human histone H3 unmodified against lysine 4 (H3K4). These beads can be used for no-wash AlphaLISA epigenetic eraser assays.
Price Range : 1213.00 EUR - 22100.00 EUR
SureFire principle

AlphaScreen SureFire Phospho-Caspase 9 (Ser196) Kit

The AlphaScreen® SureFire® p-Caspase 9 (Ser196) assay is a sandwich immunoassay for quantitative detection of phospho-Caspase 9 (phosphorylated on Ser196) in cellular lysates using Alpha Technology
Price Range : 1504.00 EUR - 16200.00 EUR

LANCE Ultra Europium-anti-di/mono-methyl-Histone H3 Lysine 27 (H3K27me2-1) Antibody

Europium-labeled monoclonal antibody recognizing human Histone H3 mono- and di-methylated at lysine 27 (H3K27me2-1). For use in LANCE® Ultra epigenetic writer and eraser assays.
Price Range : 2975.00 EUR - 7400.00 EUR

Anti-methyl-Histone H3 Lysine 4 (H3K4me1-2) AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against human histone H3 mono- or di-methylated at lysine 4 (H3K4me1-2). These beads can be used for no-wash AlphaLISA epigenetic writer and eraser assays.
Price Range : 1213.00 EUR - 22100.00 EUR
alphascreen surefire total

AlphaScreen SureFire GAPDH Assay Kit

The AlphaScreen® SureFire® total GAPDH assay is a sandwich immunoassay for quantitative detection of GAPDH in cellular lysates using Alpha Technology. This assay is intended to be used as a cellular normalization assay.
Price Range : 1650.00 EUR - 17800.00 EUR
PerkinElmer

LANCE Ultra Europium-anti-phospho-Histone H3 (Thr3) Antibody

Rabbit monoclonal antibody labeled with the LANCE® Europium W-1024-ITC chelate. This antibody detects peptides derived from Histone H3 phosphorylated at Thr3. Histone H3 peptides can be phosphorylated by several kinases including RSK2. Sequence motif recognized: ARTKQTARKSTGGKAPRKQLAGCG
Price Range : 1309.00 EUR - 6000.00 EUR

LANCE Ultra ULight™-MBP peptide

MBP peptide (sequence: CFFKNIVTPRTPPPSQGK-amide) labeled with the ULight™ dye. Human Myelin Basic Protein (MBP) phosphorylation site: Thr232 (Swiss-Prot: P02686); corresponds to Thr98 in other isoforms or species. MBP can be phosphorylated by a variety of kinases including ERK1/ERK2.
Price Range : 270.00 EUR - 737.00 EUR

LANCE Ultra ULight-Glycogen Synthase (Ser641/pSer657) Peptide

Glycogen synthase peptide (Sequence: PASVPPSPSLSRHSSPHQ(pS)ED) labeled with ULight™ dye. Synthetic peptide containing residues surrounding Ser641 and Ser657 of human Muscle Glycogen Synthase. This peptide is pre-phosphorylated on Ser657. Target phosphorylation site: Ser641. This peptide substrate can be phosphorylated by a variety of kinases including GSK3α and GSK3β.
Price Range : 335.00 EUR - 737.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-p70 S6 Kinase (Thr389) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-p70 S6K (Thr389) assay is a sandwich immunoassay for quantitative detection of phospho-p70 S6K (phosphorylated on Thr389) in cellular lysates using Alpha Technology.
Price Range : 493.00 EUR - 28600.00 EUR
SureFire principle

AlphaScreen SureFire Akt 1 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt1 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
Price Range : 1504.00 EUR - 16200.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-IGF-1 Receptor β (Tyr1135/1136) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-IGF-1 Receptor β (Tyr1135/1136) assay is a sandwich immunoassay for quantitative detection of phospho-IGF Receptor β (phosphorylated on Tyr1135/1136) in cellular lysates using Alpha Technology.
Price Range : 493.00 EUR - 28600.00 EUR
PerkinElmer

PDE Substrate iFL-cGMP, for LabChip EZ Reader

Fluorescently-labelled cGMP for Phosphodiesterase Assays (Enyzme inhibiton, target discovery, lead optimization)
List Price : 665.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-4E-BP1 (Thr37/46) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-4E-BP1 (Thr37/46) assay is a sandwich immunoassay for quantitative detection of phospho-4EBP1 (phosphorylated on Thr37/46) in cellular lysates using Alpha Technology.
Price Range : 493.00 EUR - 28600.00 EUR
PerkinElmer

LANCE Ultra Europium-anti-phospho-DNA Topoisomerase 2-alpha (Thr1342)

Europium-labeled mouse monoclonal antibody recognizing human DNA Topoisomerase 2-alpha phosphorylated at Thr1342. Sequence motif recognized: DEK(pT)DDE
Price Range : 1745.00 EUR - 6000.00 EUR
AlphaLISA Cellular Epigenetics kits

AlphaLISA di/mono-methylated-Histone H3 Lysine 27 (H3K27me2-1) Cellular Detection Kit

This kit is designed for the detection of di/mono-methylated Histone H3 Lysine 27 (H3K27me2-1) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 594.00 EUR - 10600.00 EUR
SureFire principle

AlphaScreen SureFire STAT3 (p-Tyr705) Assay Kit

The AlphaScreen® SureFire® p-STAT3 (p-Ser705) assay is a sandwich immunoassay for quantitative detection of phospho-STAT3 (phosphorylated on Ser705) in cellular lysates using Alpha Technology.
Price Range : 451.00 EUR - 17800.00 EUR
SureFire principle

AlphaScreen SureFire ALK (p-Tyr1604) Assay Kit

The AlphaScreen® SureFire® p-ALK (Tyr1604) assay is a sandwich immunoassay for quantitative detection of phospho-ALK (phosphorylated on Tyr1604) in cellular lysates using Alpha Technology.
Price Range : 1504.00 EUR - 16200.00 EUR
SureFire principle

AlphaScreen SureFire p-VEGF2 Receptor (Tyr1175) research kit

The AlphaScreen® SureFire® p-VEGFR2 Receptor (p-Tyr1175) assay is a sandwich immunoassay for quantitative detection of phospho-VEGF2 Receptor (phosphorylated on Tyr1175) in cellular lysates using Alpha Technology.
Price Range : 1650.00 EUR - 17800.00 EUR

LANCE Ultra Europium-anti-unmodified Histone H3 Lysine 4 (H3K4) Antibody

Europium-labeled monoclonal antibody recognizing human Histone
H3 that is unmodified at lysine 4 (H3K4). For use in LANCE® Ultra epigenetic writer and eraser assays.
Price Range : 2975.00 EUR - 7400.00 EUR
SureFire principle

AlphaScreen SureFire p-Smad3 (Ser423/425) research kit

The AlphaScreen® SureFire® p-SMAD3 (p-Ser423/425) assay is a sandwich immunoassay for quantitative detection of phospho-SMAD3 (phosphorylated on Ser423/425) in cellular lysates using Alpha Technology.
Price Range : 1650.00 EUR - 17800.00 EUR

LANCE® Eu-W1024 Anti-phosphotyrosine (P-Tyr-100)

Europium-labeled anti-phosphotyrosine (P-Tyr-100) antibody, for use in LANCE® TR-FRET kinase assays.
Price Range : 180.00 EUR - 8300.00 EUR

AlphaLISA Anti-methyl Histone H3 Arginine 2 (H3R2me) Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against human Histone H3 that is methylated at arginine 2 (H3R2me). These beads can be used for AlphaLISA no-wash epigenetic writer and eraser assays.
Price Range : 1213.00 EUR - 22100.00 EUR
SureFire principle

AlphaScreen SureFire Phospho-c-Met (Tyr1234/1235) Assay Kit 

The AlphaScreen® SureFire® p-c-Met (Tyr1234/1235) assay is a sandwich immunoassay for quantitative detection of phospho-c-Met (phosphorylated on Tyr1234/1235) in cellular lysates using Alpha Technology.
Price Range : 1504.00 EUR - 16300.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra Total ERK 1/2 Assay Kit

The AlphaLISA® SureFire® Ultra™ Total ERK 1/2 assay is a sandwich immunoassay for quantitative detection of ERK 1/2 (both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization for phosphorylation studies.
Price Range : 493.00 EUR - 28600.00 EUR
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-IKKα (Ser176/180) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-IKKα (Ser176/180) assay is a sandwich immunoassay for quantitative detection of phospho-IKKα (phosphorylated on Ser176/180) in cellular lysates using Alpha Technology.
Price Range : 493.00 EUR - 28600.00 EUR
PerkinElmer

ProfilerPro Kinase Peptide Substrate 5, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 5 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 665.00 EUR
AlphaLISA Cellular Epigenetics kits

AlphaLISA dimethylated-Histone H3 Lysine 9 (H3K9me2) Cellular Detection Kit

This kit is designed for the detection of di-methylated Histone H3 Lysine 9 (H3K9me2) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 594.00 EUR - 10600.00 EUR

"Enzymology" 1-50 of 274 Products and Services

Per Page