PerkinElmer

Drug Discovery Reagents

OF

Drug discovery is a complex, costly, and time-consuming undertaking. And for research scientists, high-throughput screening is where the journey to discovery begins.

Your job is to move from target to hit to candidate quickly and efficiently – with as little wasted resources as possible. Our HTS screening reagents do just that, providing you with a wide range of validated reagents and kits in Alpha, LANCE®, DELFIA®, and other assay technologies.

Accelerate your workflow, while getting consistent, accurate, and physiologically relevant results.

AlphaLISA assay principle
AlphaLISA assay principle

Alpha Technology

Virtually anything can be measured with Alpha Technology quickly and easily, including enzymes, receptor-ligand interactions, low-affinity interactions, second messenger levels, DNA, RNA, proteins, protein:protein interactions, peptides, sugars and small molecules.

  • Ease-of-use: homogeneous, no-wash assay, with no separation steps
  • Fast: results in 3 hours for most applications
  • High sensitivity: detect down to femtogram levels of target
  • Large dynamic range: 4-5 logs
  • Compatible with many samples types: serum, plasma, cerbrospinal fluid (CSF), tissue extracts, cell culture supernatants, cell lysates, and more

Choose the Alpha solution that’s right for you

  • AlphaLISA® – when running large numbers of ELISA from the same sample or working with difficult matrix, serum or plasma
  • AlphaLISA SureFire Ultra and AlphaScreen SureFire – an excellent choice for studying pathways or phosphorylated proteins in whole cells, or studying endogenous receptors
  • AlphaScreen® – perfect for studying fusion-tagged proteins or protein: protein interactions, and for testing cAMP, phosphorylated peptides or samples in a simple matrix
  • Alpha Toolbox – when your target doesn’t have an off-the-shelf kit, the toolbox gives you everything you need to create your own
LANCE biomarker detection assay principle
LANCE biomarker detection assay principle

LANCE Ultra TR-FRET

From assay development to primary and secondary screening, LANCE Ultra Technology provides researchers with robust and easy-to-use assays adaptable to a variety of targets on a broad range of multimode detectors, with the fastest time-to-results in a commercially-available TR-FRET assay.

  • No-wash/separation steps
  • Homogeneous dispense-and-read technology
  • Sensitive detection
  • High reproducibility
  • Faster time-to-results
  • Easy automation
  • 384-well and 1536-well formats

LANCE and LANCE (LANthanide Chelate Excitation) Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One binding partner of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and a second one is labeled with an acceptor fluorophore (ULight™ dye). Upon excitation at 320-340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (~10 nm). This results in the emission of light detectable at 665 nm.

DELFIA_trf
DELFIA_trf

DELFIA

DELFIA (Dissociation-Enhanced Lanthanide Fluorescence Immunoassay) is a proven, robust immunodetection platform based on time-resolved fluorescence (TRF) detection. This detection method, coupled with the unique chemical properties of lanthanide chelates, makes DELFIA a superior alternative to conventional ELISA for research, drug discovery, and clinical applications.

DELFIA offers a combination of high sensitivity, wide dynamic range and long-lasting stability that traditional ELISA cannot match. 

Reporter gene assay
Reporter gene assay

Reporter Gene Assays

Whether your assay requires the sensitivity provided by high signal intensity, or the flexibility of an extended signal half-life, PerkinElmer provides a solution. Choose from one of three luciferase detection systems: neolite, britelite plus, or steadylite plus depending on the specific requirements of your experiment.
  • No more washing – just add your lites reagent of choice, mix, incubate, and read
  • Hassle-free storage – all lites reagents are designed for extended storage at 2-8 °C (no -20 °C storage required)
  • Odor-friendly, eliminates hood work – lites products do not contain DTT and do not have the hazards and repugnant odor typical of conventional luciferase detection systems
  • Excellent Z’ values – superior S/B ratios allow for excellent Z’ values in antagonist and agonist studies
ATPlite assay principle
ATPlite assay principle

ATP Quantitation

For fast, reliable detection of ATP for cell quantitation, ATPlite 1step and ATPlite are innovative technologies that measure cell proliferation and cytotoxicity in mammalian cells based on the detection of ATP using firefly luciferase.

ATPlite 1step – Highest sensitivity

  • True “mix and measure” continuous processing
  • Ultra high sensitivity, 3 times more light output than ATPlite
  • Short equilibrium time for faster processing
  • Signal half-life of 30 minutes

ATPlite – Convenient, extended Signal

  • 2-step format, non-separation assay for time course studies; lysate can be stored frozen and tested later
  • Quantitate from <5 cells/well
  • Prolonged equilibrium time for batch processing
  • Signal half-life of 5 hours
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"Drug Discovery Reagents" 1-50 of 1249 Products and Services

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CTLA-4 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) enables the quantitative determination of human CTLA-4 in buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 604.00 EUR - 14500.00 EUR

CD86 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human CD86 enables the quantitative determination of human CD86 in buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 604.00 EUR - 14500.00 EUR
AlphaLISA immunoassay kits

CXCL4/PF4 (Human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for CXCL4/PF4 enables the quantitative determination of CXCL4/PF4 in human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The assay shows minumum cross-reactivity with mouse CXCL4/PF4 and human CXCL4L1/PF4V.
Price Range : 623.00 EUR - 18700.00 EUR

AlphaLISA cAMP Detection Kit

AlphaLISA® cAMP kit for quantitative detection of cAMP. This assay can be used as a functional assay for Gs-coupled and Gi-coupled GPCR activity.
Price Range : 218.00 EUR - 2967.00 EUR

Chloramphenicol AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for Chloramphenicol enables the quantitative determination of Chloramphenicol in buffered solution, sample extracts, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 431.00 EUR - 10200.00 EUR
AlphaLISA immunoassay kits

D-dimer (human) AlphaLISA Detection Kit

The AlphaLISA® Human D-dimer Detection Kit is designed for detection and quantitation of human D-dimer in citrate plasma, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. Please note the kit shows some cross-reactivity to D-monomer.
Price Range : 2934.00 EUR - 22900.00 EUR
AlphaLisa Analyte 2

cAMP standard, solid (AlphaLISA)

cAMP standard, solid, for use in running standard curves in AlphaLISA cAMP assays. This standard is already provided in the AlphaLISA cAMP kit, but can be ordered separately.
List Price : 242.00 EUR

CHO HCP (broad reactivity) AlphaLISA Detection Kit

AlphaLISA® no-wash immunoassay kit for detection of Chinese Hamster Ovary Host Cell Proteins (CHO HCP) in buffered solution or cell culture medium.
Price Range : 1487.00 EUR - 9900.00 EUR

Host Cell Residual DNA AlphaLISA Detection Kit

The AlphaLISA® Host Cell Residual DNA Detection Kit is designed for detection and quantitation of DNA contaminants in cell culture supernatants using a homogeneous (no-wash steps, no separation steps) assay. This kit can be used with DNA from different prokaryotic and eukaryotic species.
Price Range : 700.00 EUR - 10100.00 EUR

IL-23 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human IL-23 enables the quantitative determination of human interleukin-23 in human serum, plasma, cell lysates, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 623.00 EUR - 18700.00 EUR
AlphaLisa Analyte 2

CXCL12/SDF-1 (human), liquid (AlphaLISA)

Human CXCL12 (SDF-1) standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human CXCL12 Detection Kit, but can also be ordered separately.
List Price : 235.00 EUR

FSH (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human Follicle Stimulating Hormone (FSH) Detection Kit is designed for detection and quantitation of human FSH in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 779.00 EUR - 10400.00 EUR
alphascreen surefire total

AlphaScreen SureFire GAPDH Assay Kit

The AlphaScreen® SureFire® total GAPDH assay is a sandwich immunoassay for quantitative detection of GAPDH in cellular lysates using Alpha Technology. This assay is intended to be used as a cellular normalization assay.
Price Range : 1650.00 EUR - 17800.00 EUR
AlphaLisa Analyte 2

BRCA2 (human), lyophilized (AlphaLISA)

Human BRCA2 standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human BRCA2 Detection Kit, but can also be ordered separately.
List Price : 235.00 EUR

Cardiac Troponin I (human) AlphaLISA Detection Kit

The AlphaLISA® Human cardiac Troponin I Detection Kit is designed for detection and quantitation of human cardiac Troponin I in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 2934.00 EUR - 22900.00 EUR
AlphaLISA immunoassay kits

Receptor Tyrosine-Protein Kinase ERbB-2 (HER2) AlphaLISA Detection Kit

The AlphaLISA® Human epidermal growth factor receptor 2 (ErbB-2, NEU, or HER2) Detection Kit is designed for detection and quantitation of human ErbB-2 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 1532.00 EUR - 10200.00 EUR
AlphaLISA Buffer

AlphaLISA Dissociation Buffer

Pre-formulated buffer that can be used to dissociate Protein A from IgG in bioprocess samples. This buffer is included in select AlphaLISA immunoassay kits, but can also be purchased to develop your own Alpha assay.
Price Range : 198.00 EUR - 376.00 EUR
Protein

EGFR (human), lyophilized (LANCE)

Human EGFR standard, lyophilized, for use in running standard curves in LANCE Ultra TR-FRET detection assays. This standard is already provided in the LANCE Ultra human EGFR Detection Kit, but can be ordered separately.
List Price : 306.00 EUR
alphascreen surefire total

AlphaScreen SureFire Total IkB alpha Assay Kit

The AlphaScreen® SureFire® total IκBαassay is a sandwich immunoassay for quantitative detection of IκBα(both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization for phosphorylation studies.
Price Range : 1504.00 EUR - 16300.00 EUR
Protein

Cardiac Troponin T (human), lyophilized (AlphaLISA)

Human cardiac troponin T standard, for use in running standard curves in AlphaLISA assays.
List Price : 306.00 EUR
sensilite enhanced luminescence assay system

sensilite Enhanced Flash Luminescence (Firefly Luciferase) Reporter Gene Assay System

sensilite is an Enhanced Flash Firefly luciferase detection assay system designed to detect and quantitate Firefly luciferase from cultured cells with optimum sensitivity. The assay requires the use of a luminometer equipped with a dispenser as the signal has to be read shortly after dispensing. Please note the 1,000 assay point kit will soon be available. The 100 assay point kit size is now available.
Price Range : 87.00 EUR - 719.00 EUR

Glucagon (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human Glucagon Detection Kit is designed for detection and quantitation of human glucagon in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 802.00 EUR - 10700.00 EUR
AlphaLisa Analyte 2

IL-10 (mouse), lyophilized (AlphaLISA)

Mouse Interleukin-10 (IL-10) standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Mouse IL-10 kit, but can be ordered separately.
List Price : 249.00 EUR
PerkinElmer

LANCE Ultra Europium-anti-phospho-MEK1/2 (Ser217/221) Antibody

Rabbit polyclonal antibody labeled with the LANCE® Europium W-1024-ITC chelate. This antibody detects human MEK1 phosphorylated at Ser217 and Ser221. It also reacts with MEK1 singly phosphorylated at Ser217 or Ser221. MEK1 is phosphorylated in vivo by RAF1 and COT. Homologous phosphorylation sites are found in MEK2. Sequence motif recognized: GQLIDSMANSFVG
Price Range : 1745.00 EUR - 6000.00 EUR

Anti-Histone H3 (C-term) AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads designed to capture Histone H3 in a homogeneous AlphaLISA assay for DOT1L. Use in conjunction with biotinylated anti-H3K79me2 (AL148).
Price Range : 1213.00 EUR - 22100.00 EUR
AlphaLisa Analyte 2

IgG (bovine), lyophilized (LANCE)

Bovine IgG standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra Bovine IgG TR-FRET Detection Kit, but can also be ordered separately.
List Price : 235.00 EUR
AlphaPlex-545-antibody-bead2

Anti-Mouse IgG AlphaPlex-545 (Tb) Acceptor Beads

AlphaPlex-545 (Terbium) Acceptor beads conjugated to anti-mouse IgG antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 592.00 EUR - 24300.00 EUR
AlphaLISA immunoassay kits

BRCA2 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human breast cancer type 2 susceptibility protein (BRCA2) enables the quantitative determination of human BRCA2 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 436.00 EUR - 9500.00 EUR
Protein

IL-23 (human), lyophilized (AlphaLISA)

Human IL-23 standard, for use in running standard curves in AlphaLISA assays.
List Price : 306.00 EUR
AlphaLISA immunoassay kits

EGFR (human) AlphaLISA Detection Kit

The AlphaLISA® EGFR Detection Kit is designed for detection and quantitation of human Epidermal Growth Factor Receptor (EGFR) in cell culture media, human serum, and other sample types using a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 700.00 EUR - 10100.00 EUR
AlphaLisa Analyte 2

DNA (liquid), AlphaLISA

DNA standard for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Host Cell Residual DNA kit, but can be ordered separately.
List Price : 249.00 EUR
alphascreen surefire total

AlphaScreen SureFire Total STAT3 Assay Kit

The AlphaScreen® SureFire® total STAT3 assay is a sandwich immunoassay for quantitative detection of STAT3 (both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization for phosphorylation studies.
Price Range : 412.00 EUR - 16300.00 EUR

Anti-Maltose-Binding Protein (MBP) AlphaLISA® Acceptor beads

AlphaLISA® Acceptor beads conjugated to anti-MBP (maltose-binding protein) antibody. The antibody is a rat monoclonal antibody, clone MBP 7G4. These beads can be used to capture MBP-tagged proteins for AlphaLISA no-wash assays.
Price Range : 592.00 EUR - 24300.00 EUR
AlphaLisa Analyte 2

CTLA-4 (human), lyophilized (AlphaLISA)

Human CTLA-4 standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human CTLA-4 Detection Kit, but can also be ordered separately.
List Price : 407.00 EUR
SureFire principle

AlphaScreen SureFire InsulinR (p-Tyr1150;Tyr1151) Assay Kit

The AlphaScreen® SureFire® p-Insulin Receptor (Tyr1150/1151) assay is a sandwich immunoassay for quantitative detection of phospho-Insulin Receptor (phosphorylated on Tyr1150/1151) in cellular lysates using Alpha Technology.
Price Range : 1650.00 EUR - 17800.00 EUR
AlphaLisa Analyte 2

ApoA1 (human) Iyophilized (AlphaLISA)

Human Apo1A standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Apo1A Detection Kit, but can be ordered separately.
List Price : 306.00 EUR

Kappa light chain (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human kappa light chain enables the quantitative determination of human kappa light chain in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 436.00 EUR - 9500.00 EUR
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 (Eu) + Total ERK 545 (Tb) Kit

The Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 + Total ERK assay kit is used to measure both the phosphorylation (Thr202/Tyr204) and total levels of endogenous “extracellular signal-regulated kinase 1 and 2” (ERK 1/2) in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure ERK 1/2 activation by either recombinant or endogenous receptors, and can be applied to primary cells.
Price Range : 752.00 EUR - 43700.00 EUR

tPA (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human tPA Detection Kit is designed for detection and quantitation of human tPA in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 802.00 EUR - 10700.00 EUR
PerkinElmer

LANCE Ultra Europium-anti-phospho-Myelin Basic Protein (MBP)

Mouse monoclonal antibody labeled with the LANCE® Eu-W1024-ITC chelate. This antibody recognizes specifically phosphorylated Thr232 in myelin basic protein (MBP; Swiss-Prot: P02686). MBP can be phosphorylated by a variety of kinases including Erk1/Erk2. Sequence motif recognized: FFKNIVTPRpTPPPSQGK
Price Range : 251.00 EUR - 5100.00 EUR

Anti-Mouse IgG2b (isotyping) AlphaLISA Acceptor beads

AlphaLISA® Acceptor beads conjugated to a anti-mouse IgG2b. This bead can be used to create no-wash AlphaLISA assays for isotyping and other applications.
Price Range : 569.00 EUR - 23400.00 EUR
AlphaLISA Cellular Epigenetics kits

AlphaLISA Human Total Histone H4 Cell-based Assay Kit

AlphaLISA no-wash assay kit for the detection of total human Histone H4 in cell extracts or cells in culture medium in a lysate transfer assay.
Price Range : 826.00 EUR - 16200.00 EUR

LANCE Ultra Europium-anti-phospho-Tyrosine Hydroxylase (Ser40) antibody

Affinity-purified rabbit polyclonal antibody labeled with the LANCE® Europium W-1024-ITC chelate. This antibody detects peptides derived from tyrosine hydroxylase and phosphorylated at serine 40. Tyrosine hydroxylase peptides can be phosphorylated by a variety of kinases including PAK2, PKC, CHK1, Aurora A and PKA. Sequence motif recognized: RRQSLIE
Price Range : 1745.00 EUR - 6000.00 EUR
Alpha_Protein_Donor_bead

Protein A Alpha Donor beads

Alpha Donor beads conjugated to Protein A. This bead can be used to capture antibodies for Alpha no-wash protein detection, antibody detection, antibody binding, and other applications.
Price Range : 485.00 EUR - 8800.00 EUR

IL-1RA (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human IL-1RA Detection Kit is designed for detection and quantitation of human interleukin-1RA in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 899.00 EUR - 12000.00 EUR
Protein

FGF23 (Human) lyophilized (AlphaLISA)

Human FGF23 standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA FGF23 Detection Kit, but can be ordered separately.
List Price : 242.00 EUR
AlphaLisa Analyte 2

Claudin 7 (human), lyophilized (AlphaLISA)

Human claudin 7 standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Human Claudin 7 Detection Kit, but can be ordered separately.
List Price : 429.00 EUR
AlphaLISA immunoassay kits

IL-17A (human) AlphaLISA Biotin-Free Detection Kit

AlphaLISA Human IL-17A Biotin-Free Detection Kit is designed for the quantitative detection of human IL-17A in serum, cell culture medium, and other samples types using a homogeneous (no wash steps, no separation steps) assay. The biotin-free kit uses anti-DIG (anti-Digoxin) Donor beads instead of streptavidin Donor beads, which makes the kit compatible with high-biotin culture media and other sample types that contain high levels biotin.
Price Range : 700.00 EUR - 10100.00 EUR
DELFIA; Eu-N1 Rabbit Anti-Mouse-IgG

DELFIA Eu-N1 Anti-Phosphtyrosine (P-Tyr-100)

Europium-labeled anti-phosphotyrosine (P-Tyr-100) antibody, for use in DELFIA® time-resolved fluorescence (TRF) kinase assays, phosphoprotein detection, and phosphoprotein binding assays.
Price Range : 206.00 EUR - 2764.00 EUR
AlphaLISA immunoassay kits

IL-13 (porcine) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for IL13 is designed for the quantitative determination of IL13 in porcine serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The assay shows minimal cross-reactivity with human IL13.
Price Range : 702.00 EUR - 10400.00 EUR

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